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FLASH GENE
Symbol OPRK1 contributors: mct - updated : 27-01-2016
HGNC name opioid receptor, kappa 1
HGNC id 8154
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
OPRK1 promoter hypermethylation might increase the risk of Alzheimer through its regulation on the gene expression of OPRK1
Susceptibility
  • to opiate addiction
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • 36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects
  • polymorphisms increasing the risk of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualanterior chamber
    agonists reduce intraocular pression by reducing aqueous humor formation and increasing aqueous humor outflow, thereby suggesting their possible usefulness in glaucoma therapy
    ANIMAL & CELL MODELS
  • Oprk1 stimulation inhibits TLR4/NfkB signaling in the rat heart subjected to myocardial ischemia and reperfusion (MI/R)