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FLASH GENE
Symbol OPLAH contributors: mlc/np - updated : 09-11-2007
HGNC name 5-oxoprolinase (ATP-hydrolysing)
HGNC id 8149
Location 8q24      Physical location : 145.106.166 - 145.115.584
Synonym name
  • pyroglutamase
  • 5-oxo-L-prolinase
  • Synonym symbol(s) OPLA, 5-Opase, DKFZP434H244
    EC.number 3.5.2.9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 8.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC286075 8q24.3 hypothetical protein LOC286075 LOC286076 8q24.3 similar to hypothetical protein ERK8  extracellular signal-regulated kinase 8 FLJ46072 8q24.3 FLJ46072 protein LOC389695 8 LOC389695 LOC389696 8 LOC389696 LOC286080 8q24.3 similar to CG3104-PA SCRIB 8q24.3 similar to CG3104-PA SIAHBP1 8q24.2-qtel similar to CG3104-PA LOC340371 8q24.3 hypothetical protein LOC340371 LOC389697 8 similar to epiplakin LOC392274 8 similar to cDNA sequence BC024139 PLEC1 8q24 plectin 1, intermediate filament binding protein 500kDa FLJ14464 8q24.3 hypothetical protein FLJ14464 GRINA 8q24 glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) MGC61633 8q24.3 similar to Putative protein C21orf56 LOC392275 8 similar to sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) OPLAH 8q24 5-oxoprolinase (ATP-hydrolysing) RRP41 8q24.3 exosome complex exonuclease RRP41 GPAA1 8q24.3 GPAA1P anchor attachment protein 1 homolog (yeast) CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3985 137.4 1288 - Watanabe (2004)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   highly
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • oxoprolinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP
  • and inorganic phosphate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS