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FLASH GENE
Symbol OPLAH contributors: mlc/np - updated : 09-11-2007
HGNC name 5-oxoprolinase (ATP-hydrolysing)
HGNC id 8149
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 8.00 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC286075 8q24.3 hypothetical protein LOC286075 LOC286076 8q24.3 similar to hypothetical protein ERK8  extracellular signal-regulated kinase 8 FLJ46072 8q24.3 FLJ46072 protein LOC389695 8 LOC389695 LOC389696 8 LOC389696 LOC286080 8q24.3 similar to CG3104-PA SCRIB 8q24.3 similar to CG3104-PA SIAHBP1 8q24.2-qtel similar to CG3104-PA LOC340371 8q24.3 hypothetical protein LOC340371 LOC389697 8 similar to epiplakin LOC392274 8 similar to cDNA sequence BC024139 PLEC1 8q24 plectin 1, intermediate filament binding protein 500kDa FLJ14464 8q24.3 hypothetical protein FLJ14464 GRINA 8q24 glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) MGC61633 8q24.3 similar to Putative protein C21orf56 LOC392275 8 similar to sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) OPLAH 8q24 5-oxoprolinase (ATP-hydrolysing) RRP41 8q24.3 exosome complex exonuclease RRP41 GPAA1 8q24.3 GPAA1P anchor attachment protein 1 homolog (yeast) CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 3985 137.4 1288 - Watanabe (2004)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Reproductivemale systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • oxoprolinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP
  • and inorganic phosphate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS