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FLASH GENE
Symbol OPCML contributors: mct - updated : 17-11-2010
HGNC name opioid binding protein/cell adhesion molecule-like
HGNC id 8143
Location 11q25      Physical location : 132.284.876 - 133.402.403
Synonym name
  • opioid-binding cell adhesion molecule
  • IgLON family member 1
  • Synonym symbol(s) OBCAM, OPCM, IGLON1
    DNA
    TYPE functioning gene
    STRUCTURE 1113.98 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    ST14 11q24-q25 suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) HSPC063 11q24.3 HSPC063 protein ADAMTS8 11q25 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 ADAMTS15 11q25 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 LOC390277 11 similar to Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (BCL2-like 7 protein) FLJ39058 11q25 hypothetical protein FLJ39058 LOC387824 11 LOC387824 MGC43033 11q25 hypothetical protein MGC43033 SNX19 11q25 sorting nexin 19 LOC219797 11q25 similar to KIAA1838 HNT 11q25 neurotrimin OPCML 11q25 opioid binding protein/cell adhesion molecule-like FLJ25851 11q25 spergen-1 LOC283172 11q25 similar to h2-calponin KIAA1030 11q25 similar to h2-calponin JAM3 11q25 junctional adhesion molecule 3 KIAA0056 11q25 KIAA0056 protein MGC10485 11q25 hypothetical protein MGC10485 THY28 11q25 thymocyte protein thy28 ACAD8 11q25 acyl-Coenzyme A dehydrogenase family, member 8 LOC112937 11q25 hypothetical protein BC011001 FLJ90231 11q25 hypothetical protein FLJ90231 LOC89944 11q25 hypothetical protein BC008326 B3GAT1 11q25 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6413 - 338 - 2003 12819783
    7 - 6300 - 345 - 2003 12819783
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrineparathyroid    
     thyroid    
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainhindbraincerebellum highly Homo sapiens
     brainforebraincerebral lobefrontal lobehighly Homo sapiens
     brainhindbrainmedulla oblongata  
     meninges   highly Homo sapiens
    Reproductivemale systemtestis   
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, lens, eye anterior segment, retina, choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three immunoglobulin-like C2-type domains
  • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • IgLON subfamily
  • CATEGORY adhesion , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • prominent expression at filopodia and cellular processes of type-1 and -2 astrocytes
  • basic FUNCTION
  • may be having an accessory role in opioid receptor function
  • synaptic cell adhesion molecule concerning synaptogenesis and its surface localization is dynamically regulated in response to neuronal activity
  • promoter methylation may play an important role in the carcinogenesis of cervical carcinoma and OPCML gene may be a cervical carcinoma-associated candidate TSG (tumor suppressor gene)
  • is stress-responsive, but this response is epigenetically impaired when its promoter becomes methylated
  • broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies
  • may be responsible for controlling the cell proliferation and growth in cortical astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in epithelial ovarian cancer
    tumoral     --low  
    in gliomas and others brain tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS