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FLASH GENE
Symbol OPCML contributors: mct - updated : 17-11-2010
HGNC name opioid binding protein/cell adhesion molecule-like
HGNC id 8143
Location 11q25      Physical location : 132.284.876 - 133.402.403
Synonym name
  • opioid-binding cell adhesion molecule
  • IgLON family member 1
  • Synonym symbol(s) OBCAM, OPCM, IGLON1
    DNA
    TYPE functioning gene
    STRUCTURE 1113.98 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6413 - 338 - 2003 12819783
    7 - 6300 - 345 - 2003 12819783
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrineparathyroid    
     thyroid    
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainhindbraincerebellum highly Homo sapiens
     brainforebraincerebral lobefrontal lobehighly Homo sapiens
     brainhindbrainmedulla oblongata  
     meninges   highly Homo sapiens
    Reproductivemale systemtestis   
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, lens, eye anterior segment, retina, choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three immunoglobulin-like C2-type domains
  • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • IgLON subfamily
  • CATEGORY adhesion , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • prominent expression at filopodia and cellular processes of type-1 and -2 astrocytes
  • basic FUNCTION
  • may be having an accessory role in opioid receptor function
  • synaptic cell adhesion molecule concerning synaptogenesis and its surface localization is dynamically regulated in response to neuronal activity
  • promoter methylation may play an important role in the carcinogenesis of cervical carcinoma and OPCML gene may be a cervical carcinoma-associated candidate TSG (tumor suppressor gene)
  • is stress-responsive, but this response is epigenetically impaired when its promoter becomes methylated
  • broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies
  • may be responsible for controlling the cell proliferation and growth in cortical astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in epithelial ovarian cancer
    tumoral     --low  
    in gliomas and others brain tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS