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FLASH GENE
Symbol OLIG3 contributors: - updated : 16-04-2005
HGNC name oligodendrocyte transcription factor 3
HGNC id 18003
Location 6q23.3      Physical location : 137.813.335 - 137.815.531
Synonym name class B basic helix- loop-helix protein 7
Synonym symbol(s) BHLHB7
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text during early gastrulation in the prospective dorsal spinal cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic helix-loop-helix (bHLH) domain
HOMOLOGY
Homologene
FAMILY
  • basic helix-loop-helix family of transcription factor (OLIG gene family)
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be required for oligodendrocyte and motor neuron specification in the spinal cord
  • playing an essential role in the establishment of the neural crest-lateral neural plate boundary
  • controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with the Delta/NOTCH regulatory loop to establish the boundary between the neural crest and the lateral neural plate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS