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FLASH GENE

Symbol

OLIG3

contributors: - updated : 16-04-2005

HGNC name	oligodendrocyte transcription factor 3
HGNC id	18003

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q23.3      Physical location : 137.813.335 - 137.815.531
Synonym name	class B basic helix- loop-helix protein 7
Synonym symbol(s)	BHLHB7

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	during early gastrulation in the prospective dorsal spinal cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic helix-loop-helix (bHLH) domain

HOMOLOGY

Homologene

FAMILY

basic helix-loop-helix family of transcription factor (OLIG gene family)

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be required for oligodendrocyte and motor neuron specification in the spinal cord
	playing an essential role in the establishment of the neural crest-lateral neural plate boundary
	controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with the Delta/NOTCH regulatory loop to establish the boundary between the neural crest and the lateral neural plate

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS