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FLASH GENE

Symbol

OLIG3

contributors: mct - updated : 30-01-2024

HGNC name	oligodendrocyte transcription factor 3
HGNC id	18003

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q23.3      Physical location : 137.813.335 - 137.815.531
Synonym name	class B basic helix- loop-helix protein 7
	class E basic helix-loop-helix protein 20
Synonym symbol(s)	BHLHB7, bHLHe20

DNA

TYPE	functioning gene
STRUCTURE	2.19 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_175747 1 - 2196 NP_786923 - 272 - 2005 15769945

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Adult   brain         Homo sapiens Fetal Reproductive female system ovary

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	during early gastrulation in the prospective dorsal spinal cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic helix-loop-helix (bHLH) domain

HOMOLOGY

Homologene

FAMILY

basic helix-loop-helix family of transcription factor (OLIG gene family)

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	may be required for oligodendrocyte and motor neuron specification in the spinal cord
	playing an essential role in the establishment of the neural crest-lateral neural plate boundary
	controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells
	plays different roles in regulating the development of dorsal and ventral spinal cord
	is a key factor in early cerebellar development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with the Delta/NOTCH regulatory loop to establish the boundary between the neural crest and the lateral neural plate

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS