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FLASH GENE
Symbol OLIG3 contributors: mct - updated : 30-01-2024
HGNC name oligodendrocyte transcription factor 3
HGNC id 18003
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic helix-loop-helix (bHLH) domain
HOMOLOGY
Homologene
FAMILY
  • basic helix-loop-helix family of transcription factor (OLIG gene family)
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be required for oligodendrocyte and motor neuron specification in the spinal cord
  • playing an essential role in the establishment of the neural crest-lateral neural plate boundary
  • controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells
  • plays different roles in regulating the development of dorsal and ventral spinal cord
  • is a key factor in early cerebellar development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with the Delta/NOTCH regulatory loop to establish the boundary between the neural crest and the lateral neural plate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS