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FLASH GENE

Symbol

OAZ1

contributors: mct/pgu - updated : 27-05-2011

HGNC name	ornithine decarboxylase antizyme 1
HGNC id	8095

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 2.269.519 - 2.273.486
Synonym name	antizyme 1
Synonym symbol(s)	AZ1, AZI, MGC138338, OAZ

DNA

TYPE	functioning gene
STRUCTURE	3.97 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004152 5 - 1146 - 228 - 2002 12426106

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately   salivary gland       highly   stomach       highly Lymphoid/Immune tonsils       highly Skin/Tegument skin       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	localize to centrosomes and modulate centrosome overproduction

basic FUNCTION	programming ribosomal frameshifting
	modulating the rate of ODC1 degradation
	catalyzing the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis, and playing a role in the regulation of polyamine synthesis (negative regulator of cellular polyamines)
	can alter the intensity and duration of the BMP stimulus through SMAD6 and the tissue-specific expression of OAZ1 is a critical determinant of the cellular response to the BMP signal
	ODC1, OAZ1 and AZIN1 play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions
	inactivates ODC1 and targets it to ubiquitin-independent degradation by the 26S proteasome
	mediator of ubiquitin-independent degradation and a suspected tumor suppressor
	restrains the assembly of centrioles by controlling the levels of centrosomal TTK through the CDK2-regulated TTK degradation signal

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SNIP1
	interacting with AURKAIP1 (AURKAIP1, OAZ1 and Aurora-A could exist as a ternary complex and AURKAIP1 enhances the interaction between OAZ1 and Aurora-A)
	positive regulator of ODC1 that is homologous to ODC1, exists predominantly as a monomer and lacks decarboxylase activity
	exerts its effect on centrosomes via TTK (promotes the removal of TTK from centrosomes, and centrosome overproduction caused by reducing OAZ1 activity requires TTK)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS