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FLASH GENE
Symbol OAZ1 contributors: mct/pgu - updated : 27-05-2011
HGNC name ornithine decarboxylase antizyme 1
HGNC id 8095
Location 19p13.3      Physical location : 2.269.519 - 2.273.486
Synonym name antizyme 1
Synonym symbol(s) AZ1, AZI, MGC138338, OAZ
DNA
TYPE functioning gene
STRUCTURE 3.97 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1146 - 228 - 2002 12426106
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 salivary gland   highly
 stomach   highly
Lymphoid/Immunetonsils   highly
Skin/Tegumentskin   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text
  • localize to centrosomes and modulate centrosome overproduction
  • basic FUNCTION
  • programming ribosomal frameshifting
  • modulating the rate of ODC1 degradation
  • catalyzing the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis, and playing a role in the regulation of polyamine synthesis (negative regulator of cellular polyamines)
  • can alter the intensity and duration of the BMP stimulus through SMAD6 and the tissue-specific expression of OAZ1 is a critical determinant of the cellular response to the BMP signal
  • ODC1, OAZ1 and AZIN1 play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions
  • inactivates ODC1 and targets it to ubiquitin-independent degradation by the 26S proteasome
  • mediator of ubiquitin-independent degradation and a suspected tumor suppressor
  • restrains the assembly of centrioles by controlling the levels of centrosomal TTK through the CDK2-regulated TTK degradation signal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNIP1
  • interacting with AURKAIP1 (AURKAIP1, OAZ1 and Aurora-A could exist as a ternary complex and AURKAIP1 enhances the interaction between OAZ1 and Aurora-A)
  • positive regulator of ODC1 that is homologous to ODC1, exists predominantly as a monomer and lacks decarboxylase activity
  • exerts its effect on centrosomes via TTK (promotes the removal of TTK from centrosomes, and centrosome overproduction caused by reducing OAZ1 activity requires TTK)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS