SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| nuclear matrix protein in interphase and distributes to the spindle poles during mitosis |
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restricted localization of GPSM2 and NUMA1 in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance |
basic FUNCTION
| required for spindle-pole assembly and maintenance |
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formation of spindle-poles, dynein, dynactin dependent |
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cell cycle-related protein essential for normal mitosis that is degraded in early apoptosis |
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intact NUMA1 is a structural element in maintaining nuclear integrity |
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functions as an essential tether linking bulk microtubules of the spindle to centrosomes |
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plays a specific role in the organization of the mitotic spindle |
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may provide structural support in the interphase nucleus by contributing to the organization of chromatin |
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critical functions for NUMA1, DCTN1 and GPSM2 in mammalian development |
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NUMA1, DCTN1 and GPSM2 are involved in spindle orientation regulation |
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plays a central role in the assembly and maintenance of spindle poles |
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might contribute to the maintenance of spindle morphology in somatic cell nuclear transfer embryos |
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KATNB1 regulates microtubule (MT) remodeling in combination with NUMA1 (nuclear mitotic apparatus protein) and cytoplasmic dynein |