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FLASH GENE
Symbol NUMA1 contributors: mct - updated : 09-09-2015
HGNC name nuclear mitotic apparatus protein 1
HGNC id 8059
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, checkpoint, M exit
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain
  • a novel RXXPDG motif mediating the binding to tankyrases
  • HOMOLOGY
    Homologene
    FAMILY ezrin-radixin-moesin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    text
  • nuclear matrix protein in interphase and distributes to the spindle poles during mitosis
  • restricted localization of GPSM2 and NUMA1 in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance
  • basic FUNCTION
  • required for spindle-pole assembly and maintenance
  • formation of spindle-poles, dynein, dynactin dependent
  • cell cycle-related protein essential for normal mitosis that is degraded in early apoptosis
  • intact NUMA1 is a structural element in maintaining nuclear integrity
  • functions as an essential tether linking bulk microtubules of the spindle to centrosomes
  • plays a specific role in the organization of the mitotic spindle
  • may provide structural support in the interphase nucleus by contributing to the organization of chromatin
  • critical functions for NUMA1, DCTN1 and GPSM2 in mammalian development
  • NUMA1, DCTN1 and GPSM2 are involved in spindle orientation regulation
  • plays a central role in the assembly and maintenance of spindle poles
  • might contribute to the maintenance of spindle morphology in somatic cell nuclear transfer embryos
  • KATNB1 regulates microtubule (MT) remodeling in combination with NUMA1 (nuclear mitotic apparatus protein) and cytoplasmic dynein
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text mitotic
    PATHWAY
    metabolism
    signaling
    nuclear biogenesis
    a component
  • part of dynactin complex required for the cytoplasmic dynein-driven movement of organelles along microtubules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTR1B
  • cytoplasmic dynein, ARP1 of the dynactin complex
  • interacting with tankyrases (interaction contributing to colocalization of tankyrase and NUMA1 at mitotic spindle poles)
  • interacting with HTT (regulates spindle orientation by ensuring the proper localization of the DCTN1 subunit of dynactin, dynein and NUMA1)
  • during mitosis KIF11 appears to interact with NUMA1 in the vicinity of the spindle poles, whereas the interaction does not occur in interphase cells, where KIF11 is distributed throughout the cytoplasm but NUMA1 exclusively localizes to the nucleus
  • NUP188 interacts with NUMA1, which plays an instrumental role in focusing microtubules at centrosomes, and NUMA1 localization to spindle poles is perturbed in NUP188-depleted cells
  • NUMA1 anaphase localization is independent of GPSM2 and EPB41 interactions, revealing two distinct mechanisms responsible for NUMA1 cortical recruitment at different stages of mitosis
  • TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NUMA1, and both CEP170 and NUMA1 are TBK1 substrates
  • activated EZR controls MISP levels to ensure correct NUMA1 polarization and spindle orientation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(11;17) (q13;q21), 5'-NUMA1-RARA-3'
    Susceptibility to breast cancer
    Variant & Polymorphism SNP A794G strong association with breast cancer risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS