| basic FUNCTION
| hydrolyzes oxidized purine nucleotides 8-oxo-2'-deoxyguanosine triphosphate (8-oxo-dGTP), 2-OH-dATP or their ribo-forms to their monophosphates, thus minimizing replicational and transcriptional errors both in the nuclei and mitochondria |
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preventing microincorporation of 8-oxoguanine into DNA, therefore preventing (AT to GT) transversion mutations to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways in mouse |
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plays an important role in protecting cells against H(2)O(2)-induced apoptosis via a Noxa- and caspase-3/7-mediated signaling pathway, thus conferring a survival advantage through the inhibition of oxidative-stress-induced DNA damage  |
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cleaves 8-oxo-dGTP but not 8-oxo-dGDP |
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NUDT1, NUDT15, NUDT18 may function together to help maintain the high fidelity of DNA replication and transcription under oxidative stress |
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enzyme that hydrolyses several oxidized purine nucleoside triphosphates to their corresponding nucleoside monophosphates |
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is a novel and critical component of oncogenic KRAS-associated malignancy and its inhibition is likely to yield significant tumor-suppressive outcomes in KRAS-driven tumors |
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is the most prominent sanitizer of the cellular deoxyribonucleoside triphosphates (dNTPs) pool known to date |
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protein enzyme that can help to prevent 8-oxo-dGTP misincorporation, plays critical roles in oxidative stress neutralization, oncogene-associated tumor malignancy, and anticancer therapies |
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hydrolyzes oxidatively damaged nucleoside triphosphates and is the main enzyme responsible for nucleotide sanitization |
