| 1 | NUDT1
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| Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.
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| Waz S, Nakamura T, Hirata K, Koga-Ogawa Y, Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y, Yamagata Y.
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| J Biol Chem 292(7):2785-2794. doi: 10.1074/jbc.M116.749713. Epub 2016 Dec 29.
2017
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| 2 | NUDT1
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| Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.
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| Bräutigam L, Pudelko L, Jemth AS, Gad H, Narwal M, Gustafsson R, Karsten S, Carreras Puigvert J, Homan E, Berndt C, Berglund UW, Stenmark P, Helleday T.
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| Cancer Res 76(8):2366-75. doi: 10.1158/0008-5472.CAN-15-2380. Epub 2016 Feb 9.
2016
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| 3 | NUDT1
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| Investigation of MTH1 activity via mismatch-based DNA chain elongation.
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| Gao T, Gu S, Liu F, Li L, Wang Z, Yang J, Li G.
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| Anal Chim Acta 905:66-71. doi: 10.1016/j.aca.2015.12.011. Epub 2015 Dec 17.
2016
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| 4 | NUDT1, NUDT15
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| Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
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| Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P.
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| Nat Commun 6:7871. doi: 10.1038/ncomms8871.
2015
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| 5 | NUDT1
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| MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.
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| Patel A, Burton DG, Halvorsen K, Balkan W, Reiner T, Perez-Stable C, Cohen A, Munoz A, Giribaldi MG, Singh S, Robbins DJ, Nguyen DM, Rai P.
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| Oncogene 34(20):2586-96. doi: 10.1038/onc.2014.195. Epub 2014 Jul 14.
2015
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| 6 | NUDT1
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| Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.
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| Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y.
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| Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 1):45-8. doi: 10.1107/S1744309112048002. Epub 2012 Dec 20.
2013
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| 7 | NUDT1, NUDT15, NUDT18
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| Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
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| Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M.
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| J Biol Chem 287(25):21541-9. doi: 10.1074/jbc.M112.363010. Epub 2012 May 3.
2012
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| 8 | NUDT1
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| Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.
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| Song XN, Zhang LQ, Liu DG, Lin J, Zheng JD, Dai DP, Hei AL, Hayakawa H, Sekiguchi M, Cai JP.
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| Neurochem Res 36(8):1558-65. doi: 10.1007/s11064-011-0484-4. Epub 2011 May 3.
2011
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| 9 | NUDT1
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| hMTH1 depletion promotes oxidative-stress-induced apoptosis through a Noxa- and caspase-3/7-mediated signaling pathway.
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| Youn CK, Jun JY, Hyun JW, Hwang G, Lee BR, Chung MH, Chang IY, You HJ.
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| DNA Repair (Amst) 7(11):1809-23. doi: 10.1016/j.dnarep.2008.07.010. Epub 2008 Aug 29.
2008
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| 10 | NUDT1
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| The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.
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| Sakai Y, Oda H, Yoshimura D, Furuichi M, Kang D, Iwai S, Hara T, Nakabeppu Y.
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| J Mol Med 84(8):660-70. Epub 2006 Apr 11. 2006
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| 11 | NUDT1
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| Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.
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| Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M.
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| J Biol Chem 279(32):33806-15. Epub 2004 May 7. 2004
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| 12 | NUDT1
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| Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus.
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| Miyako K, Kohno H, Ihara K, Kuromaru R, Matsuura N, Hara T.
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| Endocr J 51(5):493-8. 2004
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| 13 | NUDT1, NUDT5
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| A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.
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| Ishibashi T, Hayakawa H, Sekiguchi M.
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| EMBO Rep 4(5):479-83. 2003
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| 14 | NUDT1
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| Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
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| Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H.
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| Nucleic Acids Res 29(2):449-54. 2001
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| 15 | NUDT1
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| Mutation analysis of the hMTH1 gene in sporadic human ovarian cancer.
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| Takama F, Kanuma T, Wang D, Nishida JI, Nakabeppu Y, Wake N, Mizunuma H.
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| Int J Oncol 17(3):467-71. 2000
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| 16 | NUDT1, NUDT2, NUDT3, NUDT5, NUDT6
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| The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review).
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| McLennan AG.
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| Int J Mol Med 4(1):79-89. Review 1999
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| 17 | NUDT1
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| Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.
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| Oda H, et al.
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| Nucleic Acids Res 27(22):4335-4343 1999
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| 18 | NUDT1
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| Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity.
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| Cai JP, et al.
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| Nucleic Acids Res 25 : 1170-1176. 1997
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| 19 | NUDT1, NUDT2, NUDT3, NUDT5, NUDT6
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| The MutT proteins or Nudix hydrolases, a family of versatile, widely distributed, housecleaning enzymes.
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| Bessman MJ, et al.
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| J Biol Chem 271(41):25059-62. Review. No abstract available 1996
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| 20 | NUDT1
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| Human diadenosine 5'-5'''-p1,p4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases.
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| Thorne NM, et al.
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| Biochem J 311 : 717-721. 1995
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| 21 | NUDT1
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| Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-Oxo-dGTPase for prevention of A:T to C:G transversion.
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| Furuichi M, et al.
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| Genomics 24 : 485-490. 1994
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| 22 | NUDT1
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| Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
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| Sakumi K, et al.
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| J Biol Chem 268 : 23524-23530. 1993
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