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FLASH GENE

Symbol

NTF4

contributors: mct/npt - updated : 10-02-2016

HGNC name	neurotrophin 4
HGNC id	8024

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GLC1O glaucoma, primary open angle, O
Location	19q13.33      Physical location : 49.564.398 - 49.567.124
Synonym name	DNA segment, single copy, probe Nt-4
	neurotrophin 5 (neurotrophin 4/5)
	neurotrophic factor 5
Synonym symbol(s)	D19S202E, NT4, NT5, NTF5, NT-4/5

DNA

TYPE	functioning gene
STRUCTURE	3.84 kb     2 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006179 2 - 999 NP_006170 22 210 - Curtis (1995)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Reproductive female system ovary         female system placenta       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

neurotrophic factors family

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	involved in the regulation of skin innervation
	controlling survival and differentiation of neurons
	influence airway smooth muscle calcium and force regulation and may have a potential role in airway diseases (Prakash 2006)
	essential role of the neurotrophin signaling system in preventing neuronal degeneration (Pasutto 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand for NTRK2 (TRKB)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GLC1O

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in atopic dermatitis constitutional     --over   significantly higher in bipolar disorder patients than in controls and in mania, depression and euthymia (Walz 2009) constitutional     --over   elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS