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FLASH GENE
Symbol NTF4 contributors: mct/npt - updated : 10-02-2016
HGNC name neurotrophin 4
HGNC id 8024
DNA
TYPE functioning gene
STRUCTURE 3.84 kb     2 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 999 22 210 - Curtis (1995)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Reproductivefemale systemovary   
 female systemplacenta   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • neurotrophic factors family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the regulation of skin innervation
  • controlling survival and differentiation of neurons
  • influence airway smooth muscle calcium and force regulation and may have a potential role in airway diseases (Prakash 2006)
  • essential role of the neurotrophin signaling system in preventing neuronal degeneration (Pasutto 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for NTRK2 (TRKB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GLC1O
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atopic dermatitis
    constitutional     --over  
    significantly higher in bipolar disorder patients than in controls and in mania, depression and euthymia (Walz 2009)
    constitutional     --over  
    elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS