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FLASH GENE
Symbol NR1I3 contributors: mct - updated : 22-08-2015
HGNC name nuclear receptor subfamily 1, group I, member 3
HGNC id 7969
Location 1q23.3      Physical location : 161.199.457 - 161.208.000
Synonym name constitutive androstane receptor-beta
Synonym symbol(s) CAR1, MB67, CAR-beta, CAR, CAR-SV4, CAR-SV8, CAR-SV13, CAR-SV21
DNA
TYPE functioning gene
STRUCTURE 8.98 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - DXS983 - DXS8079 - NR1I3 - PGK1 - DXS1002 - DXS995 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1247 - 319 - 2013 23378627
SV-22
7 - 1130 - 280 - 2013 23378627
SV-3
7 - 976 - 267 - 2013 23378627
SV-11
8 - 1093 - 306 - 2013 23378627
SV-13
8 - 1108 - 311 - 2013 23378627
SV-12
8 - 1262 - 324 - 2013 23378627
SV-6
8 - 1120 - 315 - 2013 23378627
SV-7
8 - 1116 - 296 - 2013 23378627
SV-8
8 - 1270 - 309 - 2013 23378627
SV-5 or CAR3
8 - 1285 - 314 - 2013 23378627
9 - 1387 - 348 - 2013 23378627
WT or REF
9 - 1245 - 339 - 2013 23378627
SV-14
9 - 1399 - 352 - 2013 23378627
9 - 1414 - 357 - 2013 23378627
SV-25 or CAR2
- - 1248 - 340 - 2013 23378627
SV-1
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding domain proximal P box followed by a ligand binding domain
  • short N terminal domain followed by the DNA binding and ligand binding/dimerization domains
  • C4 zinc finger domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Nr1l3
    Homologene
    FAMILY nuclear receptor subfamily 1, group I
    CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    text
  • is retained in the cytoplasm of noninduced livers and translocates into the nucleus after Phenobarbital induction
  • basic FUNCTION
  • involved in the complex network of protein governing response to retinoic acid and its metabolites
  • playing an important role in the control of drug metabolism and disposition
  • key transcription factor regulating phenobarbital (PB)-inducible transcription of various hepatic genes that encode xenobiotic/steroid-metabolizing enzymes
  • regulates serum triglyceride levels under conditions of metabolic stress
  • its activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease
  • plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters
  • able to modulate the metabolic fate of glucose, lipids, and bile acids, and it is also involved in cell-cell communication, regulation of the cell cycle, and chemical carcinogenesis
  • critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development.
  • role for NR1I3 in hepatic lineage commitment
  • plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    androgen receptor
    a component
  • putatively heterodimerizing with RXR(s)
  • DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NR0B1 is a novel and potent NR1I3 corepressor, suggesting that NR0B1 functions as a coordinate hepatic regulator of NR1I3 biological function
  • DDX54 is a novel NR1I3-interacting protein
  • interaction with PSMC5 (suppressor for Gal1), a subunit of the 26S proteasome
  • ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
  • CCAR1 is a novel transcriptional cofactor for NR1I3
  • CCAR1 can act as an enhancer-dependent coactivator of NR1I3 1)
  • cell & other
    REGULATION
    induced by dexamethasone
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS