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FLASH GENE
Symbol NR1I3 contributors: mct - updated : 22-08-2015
HGNC name nuclear receptor subfamily 1, group I, member 3
HGNC id 7969
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding domain proximal P box followed by a ligand binding domain
  • short N terminal domain followed by the DNA binding and ligand binding/dimerization domains
  • C4 zinc finger domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Nr1l3
    Homologene
    FAMILY nuclear receptor subfamily 1, group I
    CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    text
  • is retained in the cytoplasm of noninduced livers and translocates into the nucleus after Phenobarbital induction
  • basic FUNCTION
  • involved in the complex network of protein governing response to retinoic acid and its metabolites
  • playing an important role in the control of drug metabolism and disposition
  • key transcription factor regulating phenobarbital (PB)-inducible transcription of various hepatic genes that encode xenobiotic/steroid-metabolizing enzymes
  • regulates serum triglyceride levels under conditions of metabolic stress
  • its activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease
  • plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters
  • able to modulate the metabolic fate of glucose, lipids, and bile acids, and it is also involved in cell-cell communication, regulation of the cell cycle, and chemical carcinogenesis
  • critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development.
  • role for NR1I3 in hepatic lineage commitment
  • plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    androgen receptor
    a component
  • putatively heterodimerizing with RXR(s)
  • DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NR0B1 is a novel and potent NR1I3 corepressor, suggesting that NR0B1 functions as a coordinate hepatic regulator of NR1I3 biological function
  • DDX54 is a novel NR1I3-interacting protein
  • interaction with PSMC5 (suppressor for Gal1), a subunit of the 26S proteasome
  • ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
  • CCAR1 is a novel transcriptional cofactor for NR1I3
  • CCAR1 can act as an enhancer-dependent coactivator of NR1I3 1)
  • cell & other
    REGULATION
    induced by dexamethasone
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS