motifs/domains
| a DNA-binding domain at the N terminus |
|
a nuclear hormone receptor ligand-binding domain at the C terminus |
|
N terminus consists of three sequence repeats that include the LXXL/ML motif thought to play a role in subcellular distribution and nuclear localization of NR0B1, and were required for the full repression of NR1H4 transactivation  |
|
ligand binding domain common to nuclear receptors, lacking the zinc-finger DNA binding domain, but with 3.5 repeats motifs at the N-terminus |
|
. a C terminal LBD-like domain with transcriptional silencing domain, dominant negative regulator of transcription, with an amphipatic alpha-helical motif (AF2 domain), required for nuclear localization |
| basic FUNCTION
| DAX1 has a role in gonadal sex determination |
|
may influence the development of spermatogenic cells in response to steroid and pituitary hormones |
|
DAX1 may be one of the factors influencing the steroid biosynthesis of adrenocortical neoplasms |
|
DAX1 binds DNA and acts as a powerful transcriptional repressor of steroidogenic acute regulatory protein (STAR) gene expression |
|
DAX1 is essential for the development of a functioning hypothalamus-pituitary-gonadal axis |
|
Sry and Dax1 are both required for normal testis determination |
|
orphan nuclear (steroid/thyroid/retinoid) receptor, with a transcriptional repression activity |
|
likely involved in testis development, essential for the integrity of testicular germinal epithelium |
|
repressing STAR expression and NR5A1 (SF-1) transcription and suppressing steroidogenesis by binding to the STAR promoter |
|
antagonizing testis determining factor SRY and synergy between FTZF1 and WT1 |
|
playing a role in cutaneous steroidogenesis and in hair follicle cycling |
|
having pleiotropic roles in addition to its function as a negative regulator of steroidogenesis during the development and adult function of the hypothalamic-pituitary-adrenal-gonadal (HPAG) axis |
|
functioning as a global negative regulator of steroid hormone production by repressing the expression of multiple genes involved in the steroidogenic pathway |
|
having a function in the development of the embryo and in the maintenance of embryonic stem cell pluripotency |
|
acting as a nucleocytoplasmic shuttling protein, and may be exerting additional post-transcriptional regulatory functions |
|
required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma |
|
inhibiting the transactivity of PPARG in a dose-dependent manner |
|
functioning as a ligand-independent nuclear receptor and may be as a competitive transcriptional corepressor |
|
may function as a dosage-dependent SF-1 coactivator |
|
play a role in steroidogenesis and adrenal biology |
|
downregulates the expression of Mc2R, CYP11A1, and StAR genes |
|
is critical in early embryogenesis, where it participates in the maintenance of embryonic stem cell pluripotency |
|
acts as a transcriptional repressor in adrenal/gonadal development, steroidogenesis and probably spermatogenesis |
|
acts as a co-repressor to negatively modulate NR1H4 transactivity |
|
inhibition of its expression or activity in the liver might increase NR1H4 target gene expression and improve glucose and lipid homeostasis |
|
functions as a negative regulator of ESSRB and POU5F1, and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of ES cells |
