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FLASH GENE
Symbol NPY contributors: mct/npt - updated : 08-09-2012
HGNC name neuropeptide Y
HGNC id 7955
Location 7p15.1      Physical location : 24.323.806 - 24.331.484
Synonym name melanostatin
Synonym symbol(s) PYY4
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC340277 NPTX2 7q21.3-q22.1 neuronal pentraxin II STK31 7p15.3 serine/threonine kinase 31 LOC392982 7 similar to RIKEN cDNA 1500011L16 LOC392781 7 similar to 40S ribosomal protein S2 DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 NPY 7p15.1 neuropeptide Y TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC392782 7 LOC392782 SMURF1 7q21.1-q31.1 LOC392782 POT1 7q31.33 protection of telomeres 1 MPP6 7p15 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) LOC392754 7 similar to importin alpha 1b NPY 7p15.1 neuropeptide Y LOC392983 7 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (PRO1608) DFNA5 7p15 deafness, autosomal dominant 5 ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa OSBPL3 7p15 oxysterol binding protein-like 3 ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 KIAA0632 7q22.1 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 MPP6 7p15 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 DFNA5 7p15 deafness, autosomal dominant 5 LOC392755 7 similar to ADP-ribosylation factor 6 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 551 11 97 - Zhou (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousbraindiencephalonhypothalamus  
 nerve    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal tyrosinamide
  • HOMOLOGY
    Homologene
    FAMILY
  • NPY family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localization of CTSL1 with NPY in regulated secretory vesicles of chromaffin cells
  • basic FUNCTION
  • involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue
  • functioning as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases
  • functions as a peptide neurotransmitter and as a neuroendocrine hormone
  • in the digestive tract, NPY and PYY inhibit gastrointestinal motility and electrolyte secretion and in this way modify the input to the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SST inhibits the NPY response to hypoglycemia
  • unique function of CTSV for producing PENK and NPY neuropeptides required for neurotransmission in health and neurological diseases
  • cell & other
    REGULATION
    inhibited by leptin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
  • -485T allele may confer susceptibility to schizophrenia by decreasing the neuropeptide in brains
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS