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FLASH GENE
Symbol NPY contributors: mct/npt - updated : 08-09-2012
HGNC name neuropeptide Y
HGNC id 7955
Location 7p15.1      Physical location : 24.323.806 - 24.331.484
Synonym name melanostatin
Synonym symbol(s) PYY4
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 551 11 97 - Zhou (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousbraindiencephalonhypothalamus  
 nerve    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal tyrosinamide
    • HOMOLOGY
    Homologene
    FAMILY
  • NPY family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localization of CTSL1 with NPY in regulated secretory vesicles of chromaffin cells
    • basic FUNCTION
  • involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue
  • functioning as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases
  • functions as a peptide neurotransmitter and as a neuroendocrine hormone
  • in the digestive tract, NPY and PYY inhibit gastrointestinal motility and electrolyte secretion and in this way modify the input to the brain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SST inhibits the NPY response to hypoglycemia
  • unique function of CTSV for producing PENK and NPY neuropeptides required for neurotransmission in health and neurological diseases
    • cell & other
    REGULATION
    inhibited by leptin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
  • -485T allele may confer susceptibility to schizophrenia by decreasing the neuropeptide in brains
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS