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FLASH GENE
Symbol NPY contributors: mct/npt - updated : 08-09-2012
HGNC name neuropeptide Y
HGNC id 7955
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal tyrosinamide
  • HOMOLOGY
    Homologene
    FAMILY
  • NPY family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localization of CTSL1 with NPY in regulated secretory vesicles of chromaffin cells
  • basic FUNCTION
  • involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue
  • functioning as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases
  • functions as a peptide neurotransmitter and as a neuroendocrine hormone
  • in the digestive tract, NPY and PYY inhibit gastrointestinal motility and electrolyte secretion and in this way modify the input to the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SST inhibits the NPY response to hypoglycemia
  • unique function of CTSV for producing PENK and NPY neuropeptides required for neurotransmission in health and neurological diseases
  • cell & other
    REGULATION
    inhibited by leptin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
  • -485T allele may confer susceptibility to schizophrenia by decreasing the neuropeptide in brains
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS