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FLASH GENE
Symbol NPTX2 contributors: mct/shn - updated : 12-12-2010
HGNC name neuronal pentraxin II
HGNC id 7953
Location 7q22.1      Physical location : 98.246.596 - 98.259.181
Synonym name
  • neuronal activity-regulated pentaxin
  • apexin
  • neuronal pentraxin-2
  • Synonym symbol(s) NP2, NARP, NP-II
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE
    text Immediate-early gene (IEG) dynamically regulated by forms of synaptic activity
    STRUCTURE 12.59 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D7S491 - D7S554 - NPTX2 - D7S651 - D7S2498 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2738 - 431 highly enriched at excitatory synapses - 20729843
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveliver   lowly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemseminal vesicles  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three glycosylation sites
  • a putative leucine zipper domain
  • HOMOLOGY
    interspecies ortholog to Nptx2, Mus musculus
    ortholog to Nptx2, Rattus norvegicus
    ortholog to nptx2, Danio rerio
    ortholog to NPTX2, Pan troglodytes
    Homologene
    FAMILY neuronal petraxins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes neurite outgrowth
  • contributes to homeostatic plasticity of interneurons and is important for the activity-dependent recruitment of PV-IN–mediated inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , synaptogenesis
    text involved in excitatory synapse formation
    PATHWAY
    metabolism
    signaling
    a component component of three neuronal pentraxins (represent a novel neuronal uptake pathway that may function during synapse formation and remodeling)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • taipoxin and taipoxin-associated calcium-binding protein 49, TCBP49
  • form heterocomplexes with neuronal pentraxin 1, NP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice lacking Narp showed a marked increase in sensitivity to kindling-induced seizure