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FLASH GENE
Symbol NPTX2 contributors: mct/shn - updated : 12-12-2010
HGNC name neuronal pentraxin II
HGNC id 7953
DNA
TYPE anonymous DNA segment
SPECIAL FEATURE
text Immediate-early gene (IEG) dynamically regulated by forms of synaptic activity
STRUCTURE 12.59 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D7S491 - D7S554 - NPTX2 - D7S651 - D7S2498 - qter
Physical map
ASNS 7q21.3 asparagine synthetase LOC389534 7 LOC389534 LOC389535 7 similar to hypothetical protein LOC286031 LOC389536 7 similar to seven transmembrane helix receptor LOC389537 7 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC389538 7 similar to hypothetical protein MGC56855 OCM 7p13-p11 oncomodulin KPI2 7q22.1 oncomodulin MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein BRI3 7q22.1 brain protein I3 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate NPTX2 7q21.3-q22.1 neuronal pentraxin II DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein SMURF1 7q21.1-q31.1 transformation/transcription domain-associated protein LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2738 - 431 highly enriched at excitatory synapses - 20729843
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiens
Digestiveliver   lowly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivemale systemseminal vesicles  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three glycosylation sites
  • a putative leucine zipper domain
  • HOMOLOGY
    interspecies ortholog to Nptx2, Mus musculus
    ortholog to Nptx2, Rattus norvegicus
    ortholog to nptx2, Danio rerio
    ortholog to NPTX2, Pan troglodytes
    Homologene
    FAMILY neuronal petraxins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes neurite outgrowth
  • contributes to homeostatic plasticity of interneurons and is important for the activity-dependent recruitment of PV-IN–mediated inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , synaptogenesis
    text involved in excitatory synapse formation
    PATHWAY
    metabolism
    signaling
    a component component of three neuronal pentraxins (represent a novel neuronal uptake pathway that may function during synapse formation and remodeling)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • taipoxin and taipoxin-associated calcium-binding protein 49, TCBP49
  • form heterocomplexes with neuronal pentraxin 1, NP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice lacking Narp showed a marked increase in sensitivity to kindling-induced seizure