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FLASH GENE
Symbol NPPB contributors: mct - updated : 06-05-2015
HGNC name natriuretic peptide precursor B
HGNC id 7940
Location 1p36.22      Physical location : 11.917.521 - 11.918.992
Synonym name
  • gamma-brain natriuretic peptide
  • brain type natriuretic peptide
  • natriuretic protein
  • Synonym symbol(s) BNP, ANFB
    DNA
    TYPE functioning gene
    STRUCTURE 1.47 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure full-length promoter is more active in ventricular versus atrial myocytes and essentially inactive in fibroblasts, the distal promoter contains both positive and negative regulatory elements, a region of the proximal promoter located between -127 and -40 confers tissue specificity
    MAPPING cloned Y linked   status confirmed
    Map pter - D1S1414 - 1437 - NPPB - D1S1305 - D1S1753E - cen
    Physical map
    TARDBP 1p36.22 TAR DNA binding protein AF311304 1p36.22 hypothetical protein AF311304 MASP2 1p36.3-p36.2 mannan-binding lectin serine protease 2 SRM 1p36-p22 spermidine synthase PMSCL2 1p36.22 polymyositis/scleroderma autoantigen 2, 100kDa FRAP1 1p36.3-p36.2 FK506 binding protein 12-rapamycin associated protein 1 CDT6 1p36.3-p36.2 angiopoietin-like factor TERE1 1p36 angiopoietin-like factor KIAA1337 1p36.21 KIAA1337 protein FBXO2 1p36.21 F-box only protein 2 FBX30 1p36.21 F-box protein FBX30 FBXO6 1p36.23-p36.11 F-box only protein 6 MAD2L2 1p36 MAD2 mitotic arrest deficient-like 2 (yeast) LOC374946 1p36.21 hypothetical gene supported by AK075558; BC021286 AGTRAP 1p36.21 angiotensin II receptor-associated protein DKFZp434E1410 1p36.21 hypothetical protein DKFZp434E1410 MTHFR 1p36.3 5,10-methylenetetrahydrofolate reductase (NADPH) CLCN6 1p36.2 chloride channel 6 NPPA 1p36.2 natriuretic peptide precursor A NPPB 1p36.2 natriuretic peptide precursor B LOC390997 1 similar to SET binding factor 1 isoform a; myotubularin-related protein 5 MGC33867 1p36.21 hypothetical protein MGC33867 PLOD 1p36.31 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehlers-Danlos syndrome type VI) MFN2 1p36.21 mitofusin 2 FLJ12438 1p36.21 hypothetical protein FLJ12438 TNFRSF8 1p36 tumor necrosis factor receptor superfamily, member 8 TNFRSF1B 1p36.32 tumor necrosis factor receptor superfamily, member 1B LOC390998 1 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) FLJ10619 DHRS3 1p36.1 dehydrogenase/reductase (SDR family) member 3 LOC343066 1p36.21 similar to Arylacetamide deacetylase (AADAC)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 708 - 134 - 2008 18823968
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • conserved 17-AAs disulfide-linked ring structure that is required for biological activity
  • HOMOLOGY
    interspecies homolog to murine nppb
    Homologene
    FAMILY
  • natriuretic peptide family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • directly influencing blood pressure, body fluid homeostasis and cardiovascular improving heart function
  • functioning as a cardiac hormone
  • may also play a role in energy metabolism and metabolic diseases
  • cardiac hormone with systemic haemodynamic effects as well as local cytoprotective and antiproliferative properties
  • NPPB, NPPA, NPPC activate guanylyl cyclase suggesting a potential role in maintaining lens epithelial cell homeostasis (PMID;
  • controls early load-dependent regulation of ATP2A1 through calcineurin
  • possesses cardiorenal protective actions
  • may play an important role in regulating blood pressure and remodeling of the heart
  • involved in the endochondral ossification signalling
  • importance of the endogenous NPPA/NPPB-NPR1 system not only in the neovascularization of ischemic tissues but also in embryonic vascular development and organ morphogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target of SHOX (similar to SHOX, may play a role in chondrocyte maturation and, as a downstream target of SHOX might act as a mediator of the SHOX actions)
  • specific HIF1alpha target gene
  • SHOX2, like SHOX, regulates NPPB directly
  • GSN induces cardiomyocyte hypertrophy and NPPB expression via MAPK14 signaling and GATA4 transcriptional factor activation
  • cell & other
    REGULATION
    activated by directly activated by SHOX
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increasing progressively with worsening symptoms in severe mitral regurgitation
    constitutional     --over  
    transiently increased in patients with intracerebal large-artery atherosclerosis independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke
    constitutional     --over  
    plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions
    constitutional     --over  
    significant predictors of death and/or complicated clinical course in acute pulmonary embolism
    constitutional     --over  
    significantly with severity of mitral regurgitation secondary to ischemic and nonischemic dilated cardiomyopathy
    constitutional     --over  
    of TNNT2 and NPPB are associated with increased risk of cardioembolic and other nonlacunar ischemic strokes
    Susceptibility
  • to postmenopausal osteoporosis
  • type 2 diabetes
  • to blood pressure variation
  • Variant & Polymorphism other
  • variant increasing the risk of postmenopausal osteoporosis
  • T-381C polymorphism was associated with lower plasma glucose levels and lower type 2 diabetes risk, and with higher bone-mineral density in Japanese postmenopausal women
  • Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension
  • Candidate gene
    Marker
  • marker of preeclampsia (concentration of NPPB was higher in pre-eclamptic women, and is associated with the (TTTC) genotypes)
  • NPPB and TNNI3 are useful markers for identifying patients at risk for clinical deteriorations, and combined measurements of these biomarkers further improves the prognostic value of increased cardiovascular events in hypertrophic cardiomyopathy (HCM)
  • plasma NPPB was found to be an independent predictor of endothelial function
  • vis a useful diagnostic marker of acute Kawasaki disease in children
  • used as a therapeutic and a biomarker for heart failure (HF)
  • predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with atrial fibrillation
  • Therapy target
  • BNP level is significant and equivalent indicator of coronary artery disease and left ventricular hypertrophy in asymptomatic patients with chronic kidney disease
  • induction of NPPB may contribute to the potential benefits of pharmacological HIF inducers in the treatment of ischaemic heart disease and heart failure
  • ANIMAL & CELL MODELS