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Symbol NPPB contributors: mct - updated : 06-05-2015
HGNC name natriuretic peptide precursor B
HGNC id 7940
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
increasing progressively with worsening symptoms in severe mitral regurgitation
constitutional     --over  
transiently increased in patients with intracerebal large-artery atherosclerosis independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke
constitutional     --over  
plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions
constitutional     --over  
significant predictors of death and/or complicated clinical course in acute pulmonary embolism
constitutional     --over  
significantly with severity of mitral regurgitation secondary to ischemic and nonischemic dilated cardiomyopathy
constitutional     --over  
of TNNT2 and NPPB are associated with increased risk of cardioembolic and other nonlacunar ischemic strokes
  • to postmenopausal osteoporosis
  • type 2 diabetes
  • to blood pressure variation
  • Variant & Polymorphism other
  • variant increasing the risk of postmenopausal osteoporosis
  • T-381C polymorphism was associated with lower plasma glucose levels and lower type 2 diabetes risk, and with higher bone-mineral density in Japanese postmenopausal women
  • Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension
  • Candidate gene
  • marker of preeclampsia (concentration of NPPB was higher in pre-eclamptic women, and is associated with the (TTTC) genotypes)
  • NPPB and TNNI3 are useful markers for identifying patients at risk for clinical deteriorations, and combined measurements of these biomarkers further improves the prognostic value of increased cardiovascular events in hypertrophic cardiomyopathy (HCM)
  • plasma NPPB was found to be an independent predictor of endothelial function
  • vis a useful diagnostic marker of acute Kawasaki disease in children
  • used as a therapeutic and a biomarker for heart failure (HF)
  • predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with atrial fibrillation
  • Therapy target
  • BNP level is significant and equivalent indicator of coronary artery disease and left ventricular hypertrophy in asymptomatic patients with chronic kidney disease
  • induction of NPPB may contribute to the potential benefits of pharmacological HIF inducers in the treatment of ischaemic heart disease and heart failure