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FLASH GENE

Symbol

NOBOX

contributors: mct - updated : 23-01-2017

HGNC name	NOBOX oogenesis homeobox
HGNC id	22448

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	POF5 premature ovarian failure, 5
Location	7q35      Physical location : 144.094.332 - 144.100.786
Genatlas name	newborn ovary homeobox-encoding gene
Synonym name	similar to OG-2 homeodomain protein-like
	likely ortholog of mouse NOBOX
Synonym symbol(s)	OG2, OG-2, Og2x, TCAG_12042, POF5

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	12.99 kb     10 Exon(s)

regulatory sequence	Promoter
text structure	TAF4B occupies the proximal promoters of many essential meiosis and oogenesis regulators, including STRA8, DAZL, FIGLA, and NOBOX, and is required for their proper expression

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001080413 10 - 2076 NP_001073882 - 691 - 2006 16597639

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Reproductive female system ovary ovarian follicle   highly   male system testis

cells

System Cell Pubmed Species Stage Rna symbol Reproductive oocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to chimpanzee LOC472575
	ortholog to murine Og2x

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	(NOBOX) and LIM homeobox protein 8 (LHX8), two important regulators of postnatal oogenesis, were coexpressed with SOHLH1

basic FUNCTION	one of the first homeobox-encoding genes preferentially expressed during folliculogenesis
	involved in a signaling cascade that regulates genes necessary for oocyte and early embryo development
	oocyte-specific homeobox gene that plays a critical role in early folliculogenesis
	oocyte-specific transcriptional regulator
	critical regulator that orchestrates oocyte-specific genes such as PADI6 during folliculogenesis
	FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
	PRD-like homeodomain protein implicated in the regulation of human embryo genome activation and preimplantation embryo development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	bind to and transactivate the well-known growth differentiation factor 9 (GDF9) promoter
	NOBOX regulates the expression of GDF9

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

POF5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       ovarian failure

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles