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FLASH GENE
Symbol NOBOX contributors: mct - updated : 23-01-2013
HGNC name NOBOX oogenesis homeobox
HGNC id 22448
Corresponding disease
POF5 premature ovarian failure, 5
Location 7q35      Physical location : 144.094.332 - 144.100.786
Genatlas name newborn ovary homeobox-encoding gene
Synonym name
  • similar to OG-2 homeodomain protein-like
  • likely ortholog of mouse NOBOX
  • Synonym symbol(s) OG2, OG-2, Og2x, TCAG_12042, POF5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 12.99 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2076 - 691 - 2006 16597639
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systemovaryovarian follicle highly
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to chimpanzee LOC472575
    ortholog to murine Og2x
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • one of the first homeobox-encoding genes preferentially expressed during folliculogenesis
  • involved in a signaling cascade that regulates genes necessary for oocyte and early embryo development
  • oocyte-specific homeobox gene that plays a critical role in early folliculogenesis
  • oocyte-specific transcriptional regulator
  • critical regulator that orchestrates oocyte-specific genes such as PADI6 during folliculogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to and transactivate the well-known growth differentiation factor 9 (GDF9) promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    ovarian failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles