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FLASH GENE
Symbol NOBOX contributors: mct - updated : 23-01-2017
HGNC name NOBOX oogenesis homeobox
HGNC id 22448
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Reproductivefemale systemovaryovarian follicle highly
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to chimpanzee LOC472575
ortholog to murine Og2x
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text
  • (NOBOX) and LIM homeobox protein 8 (LHX8), two important regulators of postnatal oogenesis, were coexpressed with SOHLH1
  • basic FUNCTION
  • one of the first homeobox-encoding genes preferentially expressed during folliculogenesis
  • involved in a signaling cascade that regulates genes necessary for oocyte and early embryo development
  • oocyte-specific homeobox gene that plays a critical role in early folliculogenesis
  • oocyte-specific transcriptional regulator
  • critical regulator that orchestrates oocyte-specific genes such as PADI6 during folliculogenesis
  • FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
  • PRD-like homeodomain protein implicated in the regulation of human embryo genome activation and preimplantation embryo development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to and transactivate the well-known growth differentiation factor 9 (GDF9) promoter
  • NOBOX regulates the expression of GDF9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    ovarian failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles