| basic FUNCTION
| catalyzing the reduction of NADP(+) by NADH to NADPH and NAD(+) |
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nuclear-encoded mitochondrial protein involved in detoxification of ROS (reactive oxygen species) |
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play a role in mitochondrial oxidative phosphorylation (Scotto 2008) |
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inner mitochondrial membrane transmembrane protein involved in regenerating NADPH, coupled with proton translocation across the inner membrane  |
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novel role for NNT as a regulator of macrophage-mediated inflammatory responses. |
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may have a role in ROS detoxification in human adrenal glands |
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mitochondrial enzyme that transfers reducing equivalents from NADH to NADPH |
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role of NNT in regulating central carbon metabolism via redox balance, calling for other mechanisms that coordinate substrate preference to maintain a functional tricarboxylic acid (TCA) cycle |
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NNT functions is a high-capacity source of mitochondrial NADPH and its functional loss due to the NNT mutation results in mitochondrial redox abnormalities, most notably a poor ability to sustain NADP and glutathione in their reduced states |
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is the critical link between the metabolic and H2O2 antioxidant function in brain mitochondria |
