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FLASH GENE

Symbol

NNT

contributors: npt/mct - updated : 25-03-2015

HGNC name	nicotinamide nucleotide transhydrogenase
HGNC id	7863

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FGCD4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       uncouple beta cell mitochondrial metabolism leading to less ATP production, enhanced KATP channel activity, and consequently impaired insulin secretion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   potential therapeutic target to improve the redox balance in conditions of oxidative stress associated with neurodegenerative diseases

ANIMAL & CELL MODELS

defect in Nnt function in the mouse, and specifically within the beta-cell, leads to a reduction in insulin secretion