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FLASH GENE
Symbol NNT contributors: npt/mct - updated : 25-03-2015
HGNC name nicotinamide nucleotide transhydrogenase
HGNC id 7863
ASSOCIATED DISORDERS
corresponding disease(s) FGCD4
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
uncouple beta cell mitochondrial metabolism leading to less ATP production, enhanced KATP channel activity, and consequently impaired insulin secretion
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerative 
potential therapeutic target to improve the redox balance in conditions of oxidative stress associated with neurodegenerative diseases
ANIMAL & CELL MODELS
  • defect in Nnt function in the mouse, and specifically within the beta-cell, leads to a reduction in insulin secretion