protein
| ASC ( |
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ASC, CARD-containing protein Cardinal, and caspase-1  |
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nucleotide-binding oligomerization domain containing 2, NOD2  |
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PYCARD connects pathogen/danger sensors such as NLRP3 and NLRC4 with caspases and is involved in inflammation and cell death  |
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CASP1 interacting with PYCARD, AIM2 and NLRP3 (PYCARD inflammasomes, including AIM2 and NLRP3, are critical for CASP1 activation induced by S. pneumoniae)  |
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GBP5 promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents  |
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endogenous non-coding RNA-induced NLRP3 inflammasome activation results from DICER1 deficiency in a non-immune cell  |
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DDIT3, a protein known to regulate Ca2+ release from the ER during ER stress, amplifies NLRP3 inflammasome activation  |
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Ca2+ signaling critically regulates NLRP3 inflammasome activation by triggering mitochondrial damage  |
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EIF2AK2 physically interacts with multiple inflammasome components, including NLR family pyrin domain-containing 3 (NLRP3) |
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PYCARD interacts with NLRP3 via a homotypic PYD interaction and recruits procaspase-1 via a homotypic caspase recruitment domain interaction  |
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is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory cytokine IL1B by activating CASP1  |
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recognition of extracellular Ca2+ through CASR activates the NLRP3 inflammasome  |
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BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination  |
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TRPM2 is a key factor that links oxidative stress to the NLRP3 inflammasome activation  |
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DHX33 is a cytosolic RNA sensor that activates the NLRP3 inflammasome  |
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mitochondria play a critical role in the activation of the NLRP3 inflammasome through the direct binding of NLRP3 to cardiolipin  |
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ATG7-induced CTSB overexpression contributes to an NLRP3-dependent proinflammatory response and subsequently impairs glucose-stimulated insulin secretion (GSIS) independently of apoptosis  |
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MAVS facilitates the recruitment of NLRP3 to the mitochondria and may enhance its oligomerization and activation by bringing it in close proximity to mitochondrial reactive oxygen species  |
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MFN2 is required for the full activation of the NLRP3 inflammasomes in macrophages  |
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NLRP3 inflammasome activates CASP1, which cleaves pro–IL1B to mature forms and stimulates their secretion  |
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lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1B, via ARRB2 and HCAR1  |
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ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex  |
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is a transcriptional target of NR1I2 (NR1I2 regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells)  |
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ARRB1 plays a critical role in the assembly and activation of two major canonical inflammasomes, NLRC4, NLRP3  |
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BTK physically interacts with PYCARD and NLRP3  |
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CASP4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells  |
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PLIN2 inhibits insulin& |
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8209;induced glucose uptake by activating NLRP3, CASP1 and IL1B, leading to a decreased IRS1 expression  |
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TRIM31 is a feedback suppressor of NLRP3 inflammasome  |
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bile acids and NR1H4 play pivotal roles in sepsis via controlling the NLRP3 inflammasome  |
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endogenous NLRC3 interacts with both PYCARD and pro-caspase-1 but not with NLRP3, disrupts PYCARD speck formation through its CARD, and impairs the PYCARD and pro-caspase-1 interaction  |
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CXCL1 and CXCL2 regulate NLRP3 inflammasome activation via G-Protein-Coupled Receptor CXCR2  |
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MAP3K5, MAP3K6 was required for NLRP3 up-regulation after lipopolysaccharide treatment in primary bone marrow-derived macrophages and lung fibroblasts as well as during infection with Burkholderia thailandensis and influenza virus  |
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HSPD1 further activates NLRP3 inflammasome by elevating NLRP3 expression both at RNA and protein levels  |
| Nlrp3(-/-) mice displa high susceptiblity of infection with a pathogenic influenza A virus ( | |
mice carrying a mutation in the Nlrp3 gene produce massive amounts of IL-1beta upon stimulation with microbial stimuli, skin inflammation characterized by neutrophil infiltration and a Th17 cytokine-dominant response ( |
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Nlrp3(-/-) mice exhibited delayed neuroinflammation, demyelination, and oligodendrocyte loss  |
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ablation of Nlrp3 in mice prevents obesity-induced inflammasome activation in fat depots and liver as well as enhances insulin signaling  |
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mice lacking Nlrp3 or caspase-1 showed decreased joint pathology in an ank-deficient model of arthritis  |
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Nlrp3-/- mice are resistant to the development of Experimental autoimmune encephalomyelitis (EAE), suggesting the association of the NLRP3 inflammasome with EAE development  |