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Symbol NLRP3 contributors: mct/shn - updated : 22-09-2018
HGNC name NLR family, pyrin domain containing 3
HGNC id 16400
  • Nlrp3(-/-) mice displa high susceptiblity of infection with a pathogenic influenza A virus (
  • mice carrying a mutation in the Nlrp3 gene produce massive amounts of IL-1beta upon stimulation with microbial stimuli, skin inflammation characterized by neutrophil infiltration and a Th17 cytokine-dominant response (
  • Nlrp3(-/-) mice exhibited delayed neuroinflammation, demyelination, and oligodendrocyte loss
  • ablation of Nlrp3 in mice prevents obesity-induced inflammasome activation in fat depots and liver as well as enhances insulin signaling
  • mice lacking Nlrp3 or caspase-1 showed decreased joint pathology in an ank-deficient model of arthritis
  • Nlrp3-/- mice are resistant to the development of Experimental autoimmune encephalomyelitis (EAE), suggesting the association of the NLRP3 inflammasome with EAE development