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FLASH GENE

Symbol

NISCH

contributors: mct - updated : 22-11-2010

HGNC name	nischarin
HGNC id	18006

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.1      Physical location : 52.489.523 - 52.527.087
Synonym name	imidazoline (dihydro-imidazole) receptor
	I-1 receptor candidate protein
	imidazoline receptor antisera selected
Synonym symbol(s)	KIAA0975, FLJ14425, FLJ40413, FLJ90519, I-1, IRAS

DNA

TYPE	functioning gene
STRUCTURE	37.96 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007184 21 - 5252 NP_009115 166.6 1504 - 2000 10882231

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune thymus       highly   tonsils       highly Nervous brain       highly   spinal cord         Reproductive male system prostate     highly   male system testis     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	expressed both maternally and zygotically

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction
	N- terminus binds to the PDZ and kinase domains of LIMK1 and LIMK2
	a PX (Phox) domain, essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes
	four gelsolin-like repeats
	15 LRR (leucine-rich) repeats
	a C- terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding
	a sequence homolog to an acidic sequence of ryanodine receptors

HOMOLOGY

interspecies

homolog to C.elegans cosmid F13E9

Homologene

FAMILY

villin/gelsolin family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components
	regulates RAC1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1)
	in addition to regulating the PAK1 strand of RAC1 signaling, can also regulate other links in the web of RAC1 signaling pathways
	having functions of enhancing cell survival, growth and migration
	regulates cell migration by inhibiting p21-activated kinase (PAK1)
	may be regulating cell invasion by negative modulation of the LIMK/cofilin pathway
	nischarin small interfering RNA (siRNA) enhances cofilin phosphorylation, and may enhance random migration, resulting in stimulation of invasion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IRS1, IRS2, IRS3
	associates with LIMK1 and LIMK2 to inhibit LIMK activation, cofilin phosphorylation, and LIMK-mediated invasion of breast cancer cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate receptor for imidazolines
Marker
Therapy target	proposed target for drug action relevant to blood pressure and glucose control

ANIMAL & CELL MODELS