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FLASH GENE
Symbol NISCH contributors: mct - updated : 22-11-2010
HGNC name nischarin
HGNC id 18006
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction
  • N- terminus binds to the PDZ and kinase domains of LIMK1 and LIMK2
  • a PX (Phox) domain, essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes
  • four gelsolin-like repeats
  • 15 LRR (leucine-rich) repeats
  • a C- terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding
  • a sequence homolog to an acidic sequence of ryanodine receptors
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid F13E9
    Homologene
    FAMILY
  • villin/gelsolin family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components
  • regulates RAC1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1)
  • in addition to regulating the PAK1 strand of RAC1 signaling, can also regulate other links in the web of RAC1 signaling pathways
  • having functions of enhancing cell survival, growth and migration
  • regulates cell migration by inhibiting p21-activated kinase (PAK1)
  • may be regulating cell invasion by negative modulation of the LIMK/cofilin pathway
  • nischarin small interfering RNA (siRNA) enhances cofilin phosphorylation, and may enhance random migration, resulting in stimulation of invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IRS1, IRS2, IRS3
  • associates with LIMK1 and LIMK2 to inhibit LIMK activation, cofilin phosphorylation, and LIMK-mediated invasion of breast cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate receptor for imidazolines
    Marker
    Therapy target proposed target for drug action relevant to blood pressure and glucose control
    ANIMAL & CELL MODELS