Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NINJ1

contributors: mct/npt/shn - updated : 03-07-2018

HGNC name	ninjurin 1
HGNC id	7824

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.31      Physical location : 95.883.771 - 95.896.570
Synonym name	nerve injury-induced protein-1
Synonym symbol(s)	NIN1, NINJURIN

DNA

TYPE	functioning gene
STRUCTURE	12.82 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D9S1781 - D9S1841 - NINJ1 - D9S1803 - D9S197 - qter
Authors	Blair (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004148 4 - 1297 NP_004139 17 152 - 2017 28373430

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly   intestine small intestine     highly   liver       highly Endocrine pancreas       highly Lymphoid/Immune spleen       highly   thymus       lowly Nervous brain         Homo sapiens Reproductive female system ovary     highly   female system placenta     moderately   male system prostate     highly   male system testis     highly Respiratory lung       moderately Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma     highly Homo sapiens Nervous central       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	epithelial tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal (1–71 aa) ectodomain
	two transmembrane domains (72–100 aa and 111–138 aa),
	an intercellular region (101–110 aa)
	a domain for ninjurin-mediated homophilic adhesion
	C-terminal (139–152 aa) ectodomain

HOMOLOGY

interspecies	ortholog to Ninj1, Mus musculus
	ortholog to Ninj1, Rattus norvegicus
	homolog to LOC100333346, Danio rerio
	ortholog to NINJ1, Pan troglodytes

Homologene

FAMILY

Ninjurin family proteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	promoting axonal growth
	adhesion molecule involved in nerve regeneration in leprosy
	may be involved in the regulation of cellular senescence in the liver during carcinogenesis
	has an important role in vascular regression mediated by macrophages during early eye development and in vascular homeostasis (Lee et al, 2009)
	important cell-specific role for NINJ1 in the transmigration of inflammatory antigen-presenting cells (APCs) across the BBB, suggesting the importance of myeloid cell recruitment during the development of neuroinflammatory lesions
	adhesion molecule promoting leukocyte trafficking under inflammatory conditions
	homophilic adhesion molecule and involved in nerve regeneration
	enhances macrophage motility and consequent extravasation of immune cells through the regulation of protrusive membrane dynamics
	is a novel regulator for the angiogenic effect of PCs (pericytes), and negatively regulates the formation of neovessels, that is, the endothelial cells-tube, by reducing the trophic effects of capillary pericytes (cPCs)
	involved in macrophage migration and adhesion during inflammation
	cell surface protein known as a homophilic adhesion molecule
	adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

PATHWAY

metabolism

signaling

a component

assembles into a homomeric protein complex and N-glycosylation is a prerequisite for NINJ1 homomer assembly

INTERACTION

DNA

RNA

small molecule

protein	MMP9 cleaved NINJ1 in between Leu56 and Leu57 on its N-terminal ectodomain
	as a membrane adhesion molecule, NINJ1 is an ideal target to regulate TP53 activity via the TP53-NINJ1 loop
	regulates likely the lipopolysaccharide (LPS-induced inflammatory response through its direct binding to LPS
	NINJ1 is a target of TP53 and forms a feedback loop with TP53 by repressing TP53 mRNA translation
	depending on TP53 genetic status, NINJ1 has two opposing functions in tumorigenesis and that the NINJ1-TP53 loop may be targeted to manage inflammatory diseases and cancer

cell & other

Ninj1-expressing macrophages closely interact with hyaloid vascular endothelial cells (Lee et al, 2009)

REGULATION

induced by

up-regulated after nerve injury both in dorsal root ganglion (DRG) neurons and in Schwann cells (Araki et al, 1997)

Other	temporally increased in macrophages during regression of hyaloid vascular system (Lee et al, 2009)
	transcriptionally regulated by TP53 and can be induced by DNA damage in a TP53-dependent manner

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma tumoral     --over   in circulating prostate tumor cells

Susceptibility

to leprosy nerve damage

Variant & Polymorphism SNP	asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 1   potential therapeutic target for preventing endothelial dysfunction in diabetes mellitus immunology inflammatory   is a putative target for the treatment of inflammatory diseases, such as sepsis and inflammation-associated carcinogenesis

ANIMAL & CELL MODELS