protein
| p65 RELA |
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NKIRAS1 |
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CASP1-proteasome-dependent NFKBIA polymer degradation may contribute to cancer progression through constitutive NF-kappaB activation |
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stimulates NFKB activity by destabilizing NFKBIA protein through inducing its phosphorylation and ubiquitination |
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NFKB1 signaling pathway, which involves both NFKBIA and CHUK, plays an important role in platelet CD40 signaling, activation and aggregation in response to sCD40LG |
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omentin inhibited TNF-activated signal pathway of NFKB1 by preventing NFKB1 inhibitory protein (NFKBIA) degradation and NFKB1/DNA binding activity |
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DDRGK1 interacts with NFKBIA and regulates its stability, thereby regulates the NFKB1 transcriptional activity |
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ZBTB20 could inhibit NFKBIA transcription, govern NFKBIA protein expression, then promote NFKB1 activation, and is needed to promote full activation of TLR signaling and TLR-triggered innate immune response by selectively suppressing the suppressor NFKBIA gene transcription |
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TNFAIP8L2 inhibited the phosphorylation of AKT1, while promoting the phosphorylation of MAPK14, but had no effect on NFKBIA and ERK pathway |
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EXOC3 regulates NFKB1 transcriptional activity via the control of the phosphorylation of NFKBIA, RPS6KA2, and ERK |
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PDLIM1 negatively regulates NFKB1-mediated signaling in the cytoplasm (PDLIM1 sequestered p65 subunit of NFKB1 in the cytoplasm and suppressed its nuclear translocation in an NFKBIA-independent, but ACTN4-dependent manner |
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