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FLASH GENE
Symbol NFKBIA contributors: mct - updated : 18-03-2015
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
HGNC id 7797
DNA
TYPE functioning gene
STRUCTURE 3.24 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
C14orf147 14q13.1 chromosome 14 open reading frame 147 LOC122585 14q13.1 similar to 60S ribosomal protein L23a C14orf11 14q13 chromosome 14 open reading frame 11 SNX6 14q12 sorting nexin 6 LOC390465 14 similar to 60S ribosomal protein L23a CFL2 14q12-q13 cofilin 2 (muscle) LOC387982 14 similar to 60S RIBOSOMAL PROTEIN L12 BAZ1A 14q12-q13 bromodomain adjacent to zinc finger domain, 1A LOC390466 14 similar to SMT3 suppressor of mif two 3 homolog 2 LOC338902 14q13.2 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) SRP54 14q12-q13 signal recognition particle 54kDa C14orf24 14q13.2 chromosome 14 open reading frame 24 C14orf10 14q12 chromosome 14 open reading frame 10 KIAA0391 14q13.1-q21.2 chromosome 14 open reading frame 10 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like LOC390468 14 similar to Plasmodium falciparum trophozoite antigen r45-like protein LOC390469 14 similar to interleukin enhancer binding factor 2 MBIP 14q13 similar to interleukin enhancer binding factor 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1579 - 317 - 2000 11106428
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinepancreas   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear export signal NES in the N terminal domain
  • five copies of the ankyrin repeat (ankyrin region)
  • a consensus sequence for PKC phosphorylation and
  • a C terminal PEST sequence
  • HOMOLOGY
    Homologene
    FAMILY NF-Kappa B inhibitor family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text continuously shuttling between nucleus and cytoplasm
    basic FUNCTION
  • transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor alpha, sequestering NFKB in the cytoplasm, inhibiting NFKB activation after modification by UBL1
  • potential role for NFKBIA as a marker of NFKB/RELA activation in the oocyte and early embryo
  • CELLULAR PROCESS cell cycle
    cell life, antiapoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text hypoxie stress
    PATHWAY
    metabolism
    signaling
    a component
  • complex formed with TP53 dissociates in response to apoptotic stress hypoxia
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p65 RELA
  • NKIRAS1
  • CASP1-proteasome-dependent NFKBIA polymer degradation may contribute to cancer progression through constitutive NF-kappaB activation
  • stimulates NFKB activity by destabilizing NFKBIA protein through inducing its phosphorylation and ubiquitination
  • NFKB1 signaling pathway, which involves both NFKBIA and CHUK, plays an important role in platelet CD40 signaling, activation and aggregation in response to sCD40LG
  • omentin inhibited TNF-activated signal pathway of NFKB1 by preventing NFKB1 inhibitory protein (NFKBIA) degradation and NFKB1/DNA binding activity
  • ZBTB20 could inhibit NFKBIA transcription, govern NFKBIA protein expression, then promote NFKB1 activation, and is needed to promote full activation of TLR signaling and TLR-triggered innate immune response by selectively suppressing the suppressor NFKBIA gene transcription
  • TNFAIP8L2 inhibited the phosphorylation of AKT1, while promoting the phosphorylation of MAPK14, but had no effect on NFKBIA and ERK pathway
  • PDLIM1 negatively regulates NFKB1-mediated signaling in the cytoplasm (PDLIM1 sequestered p65 subunit of NFKB1 in the cytoplasm and suppressed its nuclear translocation in an NFKBIA-independent, but ACTN4-dependent manner
  • cell & other
    REGULATION
    Other ubiquinylated by the F box protein BTRC,component of the ubiquitin protein ligase complex (SFC) with SKP1, CUL1, RBX1, BTRC
    ASSOCIATED DISORDERS
    corresponding disease(s) ADEDAID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma
    tumoral       loss of function
    in Hodgkin and Reed-Sternberg cells
    tumoral   deletion    
    in glioblastomas
    tumoral somatic mutation      
    in Hodgkin lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS