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FLASH GENE
Symbol NFIA contributors: mct/pgu - updated : 06-04-2013
HGNC name nuclear factor I/A
HGNC id 7784
Location 1p31.3      Physical location : 61.542.945 - 61.928.459
Synonym name
  • TGGCA-binding protein
  • CCAAT-box-binding transcription factor
  • Synonym symbol(s) KIAA1439, NFI-L, NFIA2, DKFZp434L0422, DKFZp686J23256, FLJ39164, CTF
    DNA
    TYPE functioning gene
    STRUCTURE 385.52 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MPRP-1 1p32.1 metalloprotease related protein 1 TACSTD2 1p32-p31 tumor-associated calcium signal transducer 2 AK2B 1p32.1 adenylate kinase 2 pseudogene KIAA1915 1p32.1 KIAA1915 protein JUN 1p32-p31 v-jun sarcoma virus 17 oncogene homolog (avian) LOC391044 1 similar to prohibitin FLJ10986 1p32.1 hypothetical protein FLJ10986 HOOK1 1p32.1 hook homolog 1 (Drosophila) CYP2J2 1p31.3-p31.2 cytochrome P450, family 2, subfamily J, polypeptide 2 MGC34837 1p32.1 hypothetical protein MGC34837 NFIA 1p31.3-p31.2 nuclear factor I/A BBP 1p32.1 beta-amyloid binding protein precursor INADL 1p32.1-p31.3 beta-amyloid binding protein precursor FLJ10884 1p32.1 hypothetical protein FLJ10884 LOC388637 1 similar to LOC163782 protein USP1 1p32.1-p31.3 ubiquitin specific protease 1 ANGPTL3 1p31 angiopoietin-like 3 AUTL1 1p31.3 AUT-like 1, cysteine endopeptidase (S. cerevisiae) LOC199897 1p32.1 hypothetical LOC199897 LOC388638 1 LOC388638 FOXD3 1p32-p31 forkhead box D3 ALG6 1p31.3 forkhead box D3 ITGB3BP 1p31.3 integrin beta 3 binding protein (beta3-endonexin) KIAA1799 1p31.3 KIAA1799 protein PGM1 1p22.3 phosphoglucomutase 1 ROR1 1p32-p31 receptor tyrosine kinase-like orphan receptor 1 MGC35130 1p31.3 hypothetical protein MGC35130 KIAA1573 1p31.3 KIAA1573 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 9495 55.8 509 - 2004 15466411
    11 - 9339 54.9 501 - 2004 15466411
    12 - 9228 60.7 554 - 2004 15466411
    10 - 9403 54.5 498 - 2004 15466411
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum  
     brainbasal nucleicaudate nucleus  
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text expressed in the developing telencephalon
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CTF/NF-i DNA-binding domain
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • CTF/NF-I family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • neuronal subtype-enriched transcriptional regulators that participate in an intrinsic transcriptional program directing the differentiation of cerebellar granule neurons
  • play roles in patterning, glial development, cortical cell migration and axon guidance
  • transcription factor that specifies glial cell identity and promotes astrocyte differentiation during embryonic development
  • may play a role in astrocytoma biology
  • known to regulate spinal cord and neocortical development, has recently been implicated as acting downstream of NOTCH to initiate the expression of astrocyte-specific genes within the cortex
  • ZBTB20 is a key determinant of astrocytogenesis, in which it collaborates with SOX9 and NFIA, and acts in part through direct repression of POU3F2 expression
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text cellular transcription factor, functioning as a replication factor for adenovirus DNA replication
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
  • LHX2 is able to suppress NFIA-induced astrogliogenesis robustly
  • also downregulates the activity of the NOTCH signaling pathway via repression of the key NOTCH effector HES1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    disruption of murine Nfia is responsible of perinatal lethality, hydrocephalus and agenesis of the corpus callosum