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FLASH GENE
Symbol NFIA contributors: mct/pgu - updated : 06-04-2013
HGNC name nuclear factor I/A
HGNC id 7784
DNA
TYPE functioning gene
STRUCTURE 385.52 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 9495 55.8 509 - 2004 15466411
11 - 9339 54.9 501 - 2004 15466411
12 - 9228 60.7 554 - 2004 15466411
10 - 9403 54.5 498 - 2004 15466411
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Nervousbrainhindbraincerebellum  
 brainbasal nucleicaudate nucleus  
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text expressed in the developing telencephalon
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CTF/NF-i DNA-binding domain
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • CTF/NF-I family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • neuronal subtype-enriched transcriptional regulators that participate in an intrinsic transcriptional program directing the differentiation of cerebellar granule neurons
  • play roles in patterning, glial development, cortical cell migration and axon guidance
  • transcription factor that specifies glial cell identity and promotes astrocyte differentiation during embryonic development
  • may play a role in astrocytoma biology
  • known to regulate spinal cord and neocortical development, has recently been implicated as acting downstream of NOTCH to initiate the expression of astrocyte-specific genes within the cortex
  • ZBTB20 is a key determinant of astrocytogenesis, in which it collaborates with SOX9 and NFIA, and acts in part through direct repression of POU3F2 expression
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text cellular transcription factor, functioning as a replication factor for adenovirus DNA replication
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
  • LHX2 is able to suppress NFIA-induced astrogliogenesis robustly
  • also downregulates the activity of the NOTCH signaling pathway via repression of the key NOTCH effector HES1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    disruption of murine Nfia is responsible of perinatal lethality, hydrocephalus and agenesis of the corpus callosum