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FLASH GENE
Symbol NEXMIF contributors: mct - updated : 09-10-2017
HGNC name neurite extension and migration factor
HGNC id 29433
Corresponding disease
AUTSX7 autism spectrum disorder, X-linked 7
DUPXQ13 chromosome Xq13.2–13.3 duplication
MRX98 mental retardation, X-linked 98
Location Xq13.3      Physical location : -
Synonym name
  • hypothetical protein LOC340533
  • XLMR protein related to neurite extension
  • KIAA2022
    • Synonym symbol(s) bA130N24.1, RP11-130N24.1, XPN, KIAA2022, KIDLIA, MRX98
    DNA
    TYPE functioning gene
    STRUCTURE 192.60 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - XIST - DXS8066 - SLC16A2 - KIAA2022 - ABCB7 - DXS441 - DXS347 - qter
    Authors Cantagrel (04)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 11727 167 1516 - 2016 27822498
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex highly Homo sapiensFetal
     brainhindbraincerebellum  
    Reproductivefemale systemovary   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • highly expressed in postmitotic neuronsv
    • basic FUNCTION
  • may play a role in postmitotic, maturing neurons
  • may participate in neural circuit formation during developmental stages via nuclear and cytoplasmic KIAA2022
  • major role in neuron development and brain function, and is essential for proper brain development
  • regulates cell-cell and cell-matrix adhesion and cellular migration by regulating the expression of adhesion molecules
  • plays important roles in the control of neuronal migration and morphogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTSX7 , MRX98 , DUPXQ13
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    disrupted in a pericentric inversion in two mentally retarded brothers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS