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FLASH GENE
Symbol NEUROG1 contributors: mct/npt - updated : 12-06-2013
HGNC name neurogenin 1
HGNC id 7764
Location 5q31.1      Physical location : 134.869.979 - 134.871.639
Synonym name
  • neurogenic differentiation 3
  • neurogenic basic-helix-loop-helix protein
  • Synonym symbol(s) NEUROD3, AKA, NGN, Math4C, NGNR1, bHLHa6
    DNA
    TYPE functioning gene
    STRUCTURE 1.66 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure with E boxes in promoter region
    MAPPING cloned Y linked N status provisional
    Physical map
    PHF15 5q31.2 PHD finger protein 15 SARA2 5q31.1 SAR1a gene homolog 2 (S. cerevisiae) SEC24A 5 SEC24 related gene family, member A (S. cerevisiae) CAMLG 5q23 calcium modulating ligand DDX46 5q31.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y DCNP1 5q31.2 dendritic cell nuclear protein 1 LOC345607 5q31.2 similar to FLJ00292 protein NEUROG1 5q23-q31 neurogenin 1 CXCL14 5q31 chemokine (C-X-C motif) ligand 14 LOC389330 5 LOC389330 LOC389331 5 LOC389331 LOC153328 5q31.2 similar to CG4995 gene product IL9 5q31.1 interleukin 9 FBXL3B 5q31 F-box and leucine-rich repeat protein 3B LECT2 5q31.1-q32 leukocyte cell-derived chemotaxin 2 TGFBI 5q31.1 transforming growth factor, beta-induced, 68kDa DAMS 5q31.1 SMAD in the antisense orientation MADH5 5q31.1 MAD, mothers against decapentaplegic homolog 5 (Drosophila) LOC389332 5 hypothetical gene supported by BC048329 TRPC7 5q31.2 transient receptor potential cation channel, subfamily C, member 7 LOC391834 5 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1717 - 237 - Aguado-Llera (2010)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text in the developing nervous system, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic helix&
  • 8722;loop&
    8722;helix region comprising 61 AAs
    HOMOLOGY
    interspecies homolog to murine Neurod3
    Homologene
    FAMILY
  • basic helix-loop-helix (bhlh) family of transcription factors
  • "atonal" subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neurogenesis regulator D3, serving as a determination factor in neurogenesis and mediating neuronal differentiation
  • having a major role in neurogenesis to induce regulators of gene expression and signaling
  • proneural basic helix-loop-helix (bHLH) transcription factors not only initiating neuronal differentiation but also potentiating cell migration
  • transcription factor that causes neuronal differentiation and induces cortical and glutamatergic differentiation programs
  • induces glutamatergic and suppresses GABAergic neuronal differentiation during embryonic neurodevelopment (Ho 2008)
  • natively unfolded protein or intrinsically disordered protein, with a premolten globule conformation, and upon binding to two DNA E-boxes, the protein forms “fuzzy” complexes (Aguado-Llera 2010)
  • early initiator of neuronal differentiation and an inhibitor of glial differentiation (Luo 2010)
  • NEUROG1 is required to guide olfactory sensory neuron innervation of the olfactory bulb, the loss of which results in defects in olfactory bulb proliferation and tissue morphogenesis
  • NEUROG1/NEUROG2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium
  • NEUROG1 and NEUROG2 control two waves of neuronal differentiation in the piriform cortex
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • targeting MYT1, NHLH1, EBF3, EBF2, HES6, CBFA2T2, NEUROD1, NEUROD4 (bind these enhancers to activate targets that execute core programs regulating neurogenesis)
  • EYA1 and SIX1 are key transcription factors in initiating the neuronal developmental program, probably by recruiting and interacting with the SWI/SNF chromatin-remodeling complex to specifically mediate NEUROG1 and NEUROD1 transcription
  • cell & other
    REGULATION
    Other regulated by FMR1 (expression of NEUROG1 is controlled by FMR1 through the Wnt signaling pathway in adult neural progenitor/stem cells) (Luo 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other rs2344484-C-allele may affect its role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia (Ho 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS