basic FUNCTION
| neurogenesis regulator D3, serving as a determination factor in neurogenesis and mediating neuronal differentiation |
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having a major role in neurogenesis to induce regulators of gene expression and signaling |
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proneural basic helix-loop-helix (bHLH) transcription factors not only initiating neuronal differentiation but also potentiating cell migration |
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transcription factor that causes neuronal differentiation and induces cortical and glutamatergic differentiation programs |
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induces glutamatergic and suppresses GABAergic neuronal differentiation during embryonic neurodevelopment (Ho 2008) |
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natively unfolded protein or intrinsically disordered protein, with a premolten globule conformation, and upon binding to two DNA E-boxes, the protein forms “fuzzy” complexes (Aguado-Llera 2010) |
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early initiator of neuronal differentiation and an inhibitor of glial differentiation (Luo 2010) |
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NEUROG1 is required to guide olfactory sensory neuron innervation of the olfactory bulb, the loss of which results in defects in olfactory bulb proliferation and tissue morphogenesis |
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NEUROG1/NEUROG2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium |
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NEUROG1 and NEUROG2 control two waves of neuronal differentiation in the piriform cortex |