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FLASH GENE
Symbol NEK7 contributors: mct - updated : 02-06-2016
HGNC name NIMA (never in mitosis gene a)-related kinase 7
HGNC id 13386
Location 1q31.3      Physical location : 198.126.107 - 198.291.546
Synonym name NIMA-related kinase 7
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 165.44 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SLICK 1q31.2 sodium- and chloride-activated ATP-sensitive potassium channel HF1 1q32 H factor 1 (complement) FHR-3 1q32 complement factor H related 3 HFL1 1q32 H factor (complement)-like 1 FHR-4 1q32 complement factor H-related 4 HFL3 1q32 H factor (complement)-like 3 FHR5 1q22-q23 H factor (complement)-like 3 F13B 1q31 coagulation factor XIII, B polypeptide ASPM 1q31 asp (abnormal spindle)-like, microcephaly associated (Drosophila) FRBZ1 1q31.3 FRBZ1 protein LOC127011 1q31.3 similar to ATPase, H+ transporting, lysosomal accessory protein 2; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9; vacuolar ATP synthase membrane sector associated protein M8-9; V-A CRB1 1q31-q32.1 crumbs homolog 1 (Drosophila) MRPS21P3 1q31.2 mitochondrial ribosomal protein S21 pseudogene 3 FLJ20054 1q31.3 hypothetical protein FLJ20054 MGC27044 LOC388722 1 similar to Hypothetical protein CBG13135 LHX9 1q31-q32 LIM homeobox 9 NEK7 1q31.3 NIMA (never in mitosis gene a)-related kinase 7 ATP6V1G3 1q32.2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 3 PTPRC 1q31-q32.1 protein tyrosine phosphatase, receptor type, C LOC391147 1 similar to 40S ribosomal protein S2 LOC391148 1 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC391149 1 similar to 14.5 kDa translational inhibitor protein (p14.5) (UK114 antigen homolog) NR5A2 1q32.11 nuclear receptor subfamily 5, group A, member 2 LOC339521 1q31.3 similar to RIKEN cDNA 1810009O10 LOC391150 1 similar to Cofilin, non-muscle isoform LOC388723 1 hypothetical gene supported by BC040731 ZNF281 1q32.1 zinc finger protein 281 KIF14 1pter-q31.3 kinesin family member 14
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4134 - 302 - PMID: 11701951
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Nervousbrain    
Reproductivefemale systemplacenta  highly
Respiratorylung    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, G2, M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short N terminal region with regulatory role in these kinases
  • autoinhibitory tyrosine motif in the cell-cycle-regulated kinase is released through binding of NEK9
  • a core kinase domain
  • HOMOLOGY
    intraspecies paralog to NEK6
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • restricted to spindle poles in mitosis (O'Reagan 2009)
  • NEK6 and NEK7 are enriched in the centrosome
  • basic FUNCTION
  • playing a role in regulating proper spindle assembly and mitotic progression
  • mitotic kinase for chromosome condensation and segregation
  • playing a critical role for spindle assembly at prometaphase and for cytokinesis
  • play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation
  • contribute to mitotic progression downstream of another NIMA-related kinase, NEK9
  • play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis
  • with NEK6 are required for robust mitotic spindle formation and cytokinesis
  • regulator of cell division, and is an essential component for mammalian growth and survival
  • emerge as factor that function at multiple steps of progression through mitosis, as NEK6 and NEK7 have previously been shown to also support mitotic spindle formation and cytokinesis
  • NEK6 and NEK7 might be required for timely nuclear envelope permeabilization during mitotic entry
  • role of KIF11, PLK1 and the NIMA-family kinases NEK7 and NEK9 in the control of centrosome separation and normal mitotic progression
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • mitotic spindle assembly requires the regulated activities of protein kinases such as NEK7 and NEK9
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    with NEK9 and NEK6 are components of a mitotic spindle-signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NEK9
  • combined action of CDK1, NEK6, NEK7, and likely other kinases contributes to hyperphosphorylation of NUP98 during mitosis
  • cell & other
    REGULATION
    activated by NEK9 (cascade of mitotic NIMA family protein kinases whose combined function is important for mitotic progression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    of NEK7 or its close paralog, NEK6, has previously been shown to arrest cells in mitosis, mainly at metaphase
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in mouse, absence of Nek7 leads to lethality in late embryogenesis or at early post-natal stages and to severe growth retardation