basic FUNCTION
| playing a role in regulating proper spindle assembly and mitotic progression |
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mitotic kinase for chromosome condensation and segregation |
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playing a critical role for spindle assembly at prometaphase and for cytokinesis |
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play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation |
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contribute to mitotic progression downstream of another NIMA-related kinase, NEK9 |
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play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis |
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with NEK6 are required for robust mitotic spindle formation and cytokinesis |
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regulator of cell division, and is an essential component for mammalian growth and survival |
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emerge as factor that function at multiple steps of progression through mitosis, as NEK6 and NEK7 have previously been shown to also support mitotic spindle formation and cytokinesis |
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NEK6 and NEK7 might be required for timely nuclear envelope permeabilization during mitotic entry |
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role of KIF11, PLK1 and the NIMA-family kinases NEK7 and NEK9 in the control of centrosome separation and normal mitotic progression |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |
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mitotic spindle assembly requires the regulated activities of protein kinases such as NEK7 and NEK9 |
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NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology, and NEK7 regulates these processes in part through phosphorylation of the kinesin KIF11 |
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NEK7 is a general regulator of the microtubule cytoskeleton, controlling essential processes in both mitotic cells and postmitotic neurons |