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FLASH GENE
Symbol NEK7 contributors: mct - updated : 02-06-2016
HGNC name NIMA (never in mitosis gene a)-related kinase 7
HGNC id 13386
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short N terminal region with regulatory role in these kinases
  • autoinhibitory tyrosine motif in the cell-cycle-regulated kinase is released through binding of NEK9
  • a core kinase domain
  • HOMOLOGY
    intraspecies paralog to NEK6
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • restricted to spindle poles in mitosis (O'Reagan 2009)
  • NEK6 and NEK7 are enriched in the centrosome
  • basic FUNCTION
  • playing a role in regulating proper spindle assembly and mitotic progression
  • mitotic kinase for chromosome condensation and segregation
  • playing a critical role for spindle assembly at prometaphase and for cytokinesis
  • play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation
  • contribute to mitotic progression downstream of another NIMA-related kinase, NEK9
  • play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis
  • with NEK6 are required for robust mitotic spindle formation and cytokinesis
  • regulator of cell division, and is an essential component for mammalian growth and survival
  • emerge as factor that function at multiple steps of progression through mitosis, as NEK6 and NEK7 have previously been shown to also support mitotic spindle formation and cytokinesis
  • NEK6 and NEK7 might be required for timely nuclear envelope permeabilization during mitotic entry
  • role of KIF11, PLK1 and the NIMA-family kinases NEK7 and NEK9 in the control of centrosome separation and normal mitotic progression
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • mitotic spindle assembly requires the regulated activities of protein kinases such as NEK7 and NEK9
  • NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology, and NEK7 regulates these processes in part through phosphorylation of the kinesin KIF11
  • NEK7 is a general regulator of the microtubule cytoskeleton, controlling essential processes in both mitotic cells and postmitotic neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    with NEK9 and NEK6 are components of a mitotic spindle-signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NEK9
  • combined action of CDK1, NEK6, NEK7, and likely other kinases contributes to hyperphosphorylation of NUP98 during mitosis
  • NEK7 regulates dendrite morphogenesis in neurons via KIF11-dependent microtubule stabilization
  • cell & other
    REGULATION
    activated by NEK9 (cascade of mitotic NIMA family protein kinases whose combined function is important for mitotic progression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    of NEK7 or its close paralog, NEK6, has previously been shown to arrest cells in mitosis, mainly at metaphase
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in mouse, absence of Nek7 leads to lethality in late embryogenesis or at early post-natal stages and to severe growth retardation