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FLASH GENE
Symbol NCAN contributors: /np - updated : 03-02-2004
HGNC name neurocan
HGNC id 2465
Location 19p13.11      Physical location : 19.322.781 - 19.363.060
Synonym name
  • chondroitin sulfate proteoglycan 3
  • neurocan core protein
  • neurocan proteoglycan
  • Synonym symbol(s) CSPG3, NEUR, FLJ44681
    DNA
    TYPE functioning gene
    STRUCTURE 40.28 kb     15 Exon(s)
    regulatory sequence Binding site
    text structure AP1, AP2, SP1
    MAPPING cloned Y linked N status confirmed
    Map see TM6SF2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 6406 143 1321 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lectin C-type domain/ SUSHI domain
  • zn immunoglobulin-like domain and repeating motifs characteristic of hyaluronic acid-binding region of proteoglycans
  • HOMOLOGY
    interspecies homolog to murine Cspg3
    intraspecies homolog to AGC1,homolog
    Homologene
    FAMILY
  • aggrecan/versican proteoglycan family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • chondroitin sulfate proteoglycan, involved in the modulation of cell adhesion and migration (axon guidance and neurite growth)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS