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FLASH GENE
Symbol NCAN contributors: /np - updated : 03-02-2004
HGNC name neurocan
HGNC id 2465
DNA
TYPE functioning gene
STRUCTURE 40.28 kb     15 Exon(s)
regulatory sequence Binding site
text structure AP1, AP2, SP1
MAPPING cloned Y linked N status confirmed
Map see TM6SF2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 6406 143 1321 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lectin C-type domain/ SUSHI domain
  • zn immunoglobulin-like domain and repeating motifs characteristic of hyaluronic acid-binding region of proteoglycans
  • HOMOLOGY
    interspecies homolog to murine Cspg3
    intraspecies homolog to AGC1,homolog
    Homologene
    FAMILY
  • aggrecan/versican proteoglycan family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • chondroitin sulfate proteoglycan, involved in the modulation of cell adhesion and migration (axon guidance and neurite growth)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS