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FLASH GENE
Symbol NABP1 contributors: SGE/npt - updated : 15-04-2015
HGNC name nucleic acid binding protein 1
HGNC id 26232
Location 2q32.3      Physical location : -
Synonym name
  • CDNA: FLJ22833 fis, clone KAIA4266
  • single-stranded DNA-binding protein 2
  • oligonucleotide/oligosaccharide-binding fold containing 2A
  • sensor of ssDNA B2
  • Synonym symbol(s) FLJ13624, FLJ22833, MGC111163, SSB2, DKFZp667M1322, OBFC2A, SOSS-B2
    DNA
    TYPE functioning gene
    STRUCTURE 10.45 kb     6 Exon(s)
    motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3866 22.4 204 - 2006 16533169
    6 - 3465 - 124 - 2006 16533169
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunethymus   highly Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an OB (oligonucleotide/oligosaccharide binding) motif at the N-terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • OBFC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text localizes to the nucleus
    basic FUNCTION
  • playing an essential role for a wide variety of DNA metabolic processes, including DNA replication, recombination, DNA damage detection and repair
  • participating in DNA damage-response pathways (Li 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with INTS3 and C9orf80 , complex required for efficient homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-dependent signaling pathways (Li 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds single-stranded nucleic acids, but not double-stranded DNA, suggesting that it functions as a single-stranded nucleic acid binding protein
  • cell & other
    REGULATION
    Other its expression is regulated either directly or indirectly by RORgamma2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS