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FLASH GENE
Symbol NABP1 contributors: SGE/npt - updated : 15-04-2015
HGNC name nucleic acid binding protein 1
HGNC id 26232
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an OB (oligonucleotide/oligosaccharide binding) motif at the N-terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • OBFC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text localizes to the nucleus
    basic FUNCTION
  • playing an essential role for a wide variety of DNA metabolic processes, including DNA replication, recombination, DNA damage detection and repair
  • participating in DNA damage-response pathways (Li 2009)
  • SOSS complex (NABP1, NABP2, INTS3, INIP) is likely involved in the maintenance of genome stability
  • potential role for NABP2/NABP1 in the protection of newly replicated leading- and lagging-strand telomeres
  • NABP1 and 2 are single-stranded (ss) DNA- and RNA-binding proteins, and function in DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with INTS3 and C9orf80 , complex required for efficient homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-dependent signaling pathways (Li 2009)
  • components of the NABP2/NABP3-INTS3-C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maintenance of genome stability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds single-stranded nucleic acids, but not double-stranded DNA, suggesting that it functions as a single-stranded nucleic acid binding protein
  • single-stranded DNA-binding protein complex, NABP1/NABP2-INTS3 can recruit the checkpoint complex to initiate ATR signaling
  • INTS3, but not C9ORF80, affects the nucleic acid-binding ability of NABP1 and NABP2
  • INTS3 might regulate NABP1/NABP2 biological function
  • cell & other
    REGULATION
    Other its expression is regulated either directly or indirectly by RORgamma2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS