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FLASH GENE
Symbol MZF1 contributors: mct/npt - updated : 17-12-2015
HGNC name myeloid zinc finger 1
HGNC id 13108
Location 19q13.43      Physical location : 59.073.284 - 59.084.942
Synonym name
  • myeloid zinc finger
  • zinc finger protein 42 (myeloid-specific retinoic acid- responsive)
  • zinc finger and SCAN domain-containing protein 6
  • Synonym symbol(s) MZF1B, ZNF42, ZSCAN6, Zfp98, MZF-1B
    DNA
    TYPE functioning gene
    STRUCTURE 12.52 kb     6 Exon(s)
    MAPPING cloned Y linked   status confirmed
    Map cen - CALM3 - D19S241E - SULT2A1 - LIG1 LIG1 - DBP - LHB LHB - SNRP70 - HRC - CD37 - RRAS - KLK1 - SIGLEC6 - ETFB ETFB - LIM2 - PRKCG /IL11 - SYT3 - FPR1 - ZFP40 - ZNF160 - ZNF134 - ZNF132 - MZF1 - qter
    Authors Stubbs (96)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2938 82 734 - 2008 17851584
  • also called MZF1B
  • exon 1-6 including the N terminal SCAN box
  • 6 - 2620 82 734 - 2008 17851584
  • also called MZF1C/RAZ1
  • exon 1-6, deletion in 5'UTR
  • 6 initiation site 2694 - 290 myeloid cells 2008 17851584
  • also called MZF1 (A)
  • initiating through intron 5
  • - initiation site - 87 775 myeloid cells 2008 17851584
  • also called MZF2
  • N terminus different from MZF1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmyelocyte
    cell lineage hemaopoietic (myeloid) cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SCAN box (leucine rich), mediating interactions between members of a subfamily of zinc-finger transcription factors, and necessary for association with promyelocytic leukemia nuclear bodies (Noll 2008)
  • 13 zinc finger (C2H2) motifs
  • a glycine-proline-rich region between the fourth and fifth zinc finger motif
  • secondary structure each monomer consists of five alpha helices in two subdomains connected by the alpha2-alpha3 loop
    conjugated MetalloP
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family, C2H2 type, Kruppel-like
  • SCAN domain family transcription factors, KRAB subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative regulator of myelopoiesis development of neutrophilic granulocytes
  • transcription factor that plays an important role in blood cell development (Noll 2008)
  • with Sp1/Sp3 binding to the promoter region, drive the PADI1 expression (Dong 2008)
  • its activation in striatal astrocytes can enhance the biosynthesis and release of FGF2 through apomorphine (Luo 2009)
  • induces invasion and metastasis in colorectal and cervical cancer, at least in part by regulating AXL gene (Mudduluru 2010)
  • suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress
  • is likely an endogenous trigger of neuropathic pain and might serve as a potential target for preventing and treating this disorder
  • MZF1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma
  • role of MZF1 in myeloid differentiation and leukemia, and is involved in the etiology of major solid tumors
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form dimer via its highly conserved SCAN motif (Noll 2008)
  • constituent of promyelocytic leukemia nuclear bodies (PML-NBs)(Noll 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibiting granulocyte CSF(1) in vitro
  • SCAND1
  • interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis
  • interacting with FHL3
  • ZNF24 is a novel heterodimeric partner of MZF1 that also associates with PML-NBs in a unique ring-type pattern (Noll 2008)
  • binds to the AXL promoter, transactivates promoter activity, and enhances AXL-mRNA and protein expression in a dose-dependent manner (Mudduluru 2010)
  • promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B)
  • MZF1 regulates GAPDH, indicating a role for GAPDH in calcitriol-mediated signaling
  • MZF1 is a transcription factor that regulates SLC40A1 expression
  • interaction of MZF1 with the CTGF and NOV promoters in several cell types
  • cell & other
  • retinoic acid responsive
  • REGULATION
    induced by retinoic acid
    Other modified by SUMOylation, which provides further support for localization of MZF1 protein complexes to PML-NBs (Noll 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induces migration and invasion in colorectal and cervical cancer cells (Mudduluru 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • antisense oligonucleotide MZF1 is a new reagent for cancer therapy (Hsieh 2007)
  • ANIMAL & CELL MODELS