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FLASH GENE
Symbol MZF1 contributors: mct/npt - updated : 17-12-2015
HGNC name myeloid zinc finger 1
HGNC id 13108
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousnervecranial nerve  highly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmyelocyte
cell lineage hemaopoietic (myeloid) cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal SCAN box (leucine rich), mediating interactions between members of a subfamily of zinc-finger transcription factors, and necessary for association with promyelocytic leukemia nuclear bodies (Noll 2008)
  • 13 zinc finger (C2H2) motifs
  • a glycine-proline-rich region between the fourth and fifth zinc finger motif
  • secondary structure each monomer consists of five alpha helices in two subdomains connected by the alpha2-alpha3 loop
    conjugated MetalloP
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family, C2H2 type, Kruppel-like
  • SCAN domain family transcription factors, KRAB subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative regulator of myelopoiesis development of neutrophilic granulocytes
  • transcription factor that plays an important role in blood cell development (Noll 2008)
  • with Sp1/Sp3 binding to the promoter region, drive the PADI1 expression (Dong 2008)
  • its activation in striatal astrocytes can enhance the biosynthesis and release of FGF2 through apomorphine (Luo 2009)
  • induces invasion and metastasis in colorectal and cervical cancer, at least in part by regulating AXL gene (Mudduluru 2010)
  • suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress
  • is likely an endogenous trigger of neuropathic pain and might serve as a potential target for preventing and treating this disorder
  • MZF1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma
  • role of MZF1 in myeloid differentiation and leukemia, and is involved in the etiology of major solid tumors
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form dimer via its highly conserved SCAN motif (Noll 2008)
  • constituent of promyelocytic leukemia nuclear bodies (PML-NBs)(Noll 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibiting granulocyte CSF(1) in vitro
  • SCAND1
  • interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis
  • interacting with FHL3
  • ZNF24 is a novel heterodimeric partner of MZF1 that also associates with PML-NBs in a unique ring-type pattern (Noll 2008)
  • binds to the AXL promoter, transactivates promoter activity, and enhances AXL-mRNA and protein expression in a dose-dependent manner (Mudduluru 2010)
  • promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B)
  • MZF1 regulates GAPDH, indicating a role for GAPDH in calcitriol-mediated signaling
  • MZF1 is a transcription factor that regulates SLC40A1 expression
  • interaction of MZF1 with the CTGF and NOV promoters in several cell types
  • cell & other
  • retinoic acid responsive
  • REGULATION
    induced by retinoic acid
    Other modified by SUMOylation, which provides further support for localization of MZF1 protein complexes to PML-NBs (Noll 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induces migration and invasion in colorectal and cervical cancer cells (Mudduluru 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • antisense oligonucleotide MZF1 is a new reagent for cancer therapy (Hsieh 2007)
  • ANIMAL & CELL MODELS