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FLASH GENE

Symbol

MYT1L

contributors: mct/npt - updated : 03-05-2010

HGNC name	myelin transcription factor 1-like
HGNC id	7623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL2P25 chromosome 2p distal deletion
Location	2p25.3      Physical location : 1.792.886 - 2.335.045
Synonym name	murine zinc finger protein PUG1 homolog
	neural zinc finger transcription factor 1
	MyT1L protein
Synonym symbol(s)	KIAA1106, NZF1, MyT1-L

DNA

TYPE	functioning gene
STRUCTURE	542.16 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015025 25 - 7152 NP_055840 - 1184 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           spinal cord         Reproductive male system testis     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	neurons early stage of differentiation

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six C2Hc-type zinc fingers

HOMOLOGY

interspecies	homolog to murine Myt1l (93.5pc)
	homolog to rattus Myt1l (92.9pc)

intraspecies

paralog to MYT1

Homologene

FAMILY

myelin transcription factor 1 (Myt1) family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may favor the silencing of genes during neural development
	may function as a panneural transcription factor associated with neuronal differentiation
	may play a role in the development of neurons and oligodendrogalia in the CNS
	with ASCL1 and POU3F2 could directly convert fibroblasts into neurons (Vierbuchen 2010)
	may have a regulatory function in a specific phase during neuronal differentiation

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	developing nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacted with SIN3B, a protein that mediates transcriptional repression by binding to histone deacetylases (HDACs)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2P25

Susceptibility

to schizophrenia

Variant & Polymorphism other	disrupted by rare CNVs in schizophrenia patients

Candidate gene	for intellectual disability in patients with 2p25.3 (2pter) deletions.
Marker
Therapy target

ANIMAL & CELL MODELS