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FLASH GENE
Symbol MYT1L contributors: mct/npt - updated : 03-05-2010
HGNC name myelin transcription factor 1-like
HGNC id 7623
DNA
TYPE functioning gene
STRUCTURE 542.16 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 7152 - 1184 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 spinal cord    
Reproductivemale systemtestis  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neurons early stage of differentiation
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2Hc-type zinc fingers
  • HOMOLOGY
    interspecies homolog to murine Myt1l (93.5pc)
    homolog to rattus Myt1l (92.9pc)
    intraspecies paralog to MYT1
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may favor the silencing of genes during neural development
  • may function as a panneural transcription factor associated with neuronal differentiation
  • may play a role in the development of neurons and oligodendrogalia in the CNS
  • with ASCL1 and POU3F2 could directly convert fibroblasts into neurons (Vierbuchen 2010)
  • may have a regulatory function in a specific phase during neuronal differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text developing nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted with SIN3B, a protein that mediates transcriptional repression by binding to histone deacetylases (HDACs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2P25
    Susceptibility to schizophrenia
    Variant & Polymorphism other disrupted by rare CNVs in schizophrenia patients
    Candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions.
    Marker
    Therapy target
    ANIMAL & CELL MODELS